PDE5A Antibodies

AND PDE5A ELISA kits, PDE5A Proteins

Many biological assays use antibodies to detect PDE5A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE5A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE5A antibodies...

We validate the specificity of these antibodies to PDE5A by testing them on tissues known to express PDE5A positively and negatively. Browse below to find the PDE5A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE5A Infographic by Boster Bio

All PDE5A Products

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Product

Figures

Specificity

Applications

Price

Anti-PDE5A Antibody Picoband®

1 Citations 1 Q&As

Human, Rat

IHC, WB

$370
Cat # A02490-2
100 μg/vial

Anti-PDE5A Antibody

Human, Mouse, Rat

$405
Cat # A02490
100ul

PDE5A (NM_001083) Human Over-expression Lysate

Human

$960
Cat # LS008654
100 µg

PDE5A Overview

Facts about cGMP-specific 3',5'-cyclic phosphodiesterase.

PDE5A 3D structure. Source: alphafold

cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A)

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP (PubMed:9714779, PubMed:15489334).

Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). .

Gene Information

Human
Gene Name:	PDE5A
Uniprot:	O76074
Entrez:	8654

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

CGB-PDE; cGMP-binding cGMP-specific 3'-5'-cyclic nucleotide phosphodiesterase; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3'-5'-cyclic phosphodiesterase; cGMP-specific phosphodiesterase type 5A; CN5A; EC 3.1.4; EC 3.1.4.35; PDE5; phosphodiesterase 5A, cGMP-specific; phosphodiesterase isozyme 5

Molecular Weight

Mass (kDA):
99.985 kDA

Genomic Context


Human

Location:	4q26
Sequence:	4; NC_000004.12 (119494395..119628804, complement)

Tissue Specificity

Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung.

Diseases

Erectile Dysfunction
Hypertensive Disease
Pulmonary Hypertension
Cardiovascular Diseases
Heart Failure
Diabetes Mellitus
Headache
Observation Of Neuromuscular Block
Idiopathic Pulmonary Hypertension
Hypertrophy
Dyspepsia
Ischemia

Hypoxia
Malignant Neoplasms
Flushing
Hypotension Adverse Event
Pathologic Vasoconstriction
Myocardial Infarction
Fibrosis

Interacting Proteins

PRKG1

Pathways

Vasodilation
Penile Erection
Localization
Cell Proliferation
Vasoconstriction
Pathogenesis
Platelet Aggregation
Aging
Excretion
Angiogenesis
Secretion
Neurogenesis
Cell Growth

Transport
Platelet Activation
Sperm Motility
Relaxation Of Vascular Smooth Muscle
Reverse Transcription
Immune Response
Inflammatory Response

PTMs

Phosphorylation
Nitration
Carboxylation

Cleavage
Dephosphorylation
Oxidation

Prenylation

Research Areas

Lipid and Metabolism
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE5A

References

PMID: 9714779 by Loughney K., et al. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP- binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase.

PMID: 9716380 by Yanaka N., et al. Expression, structure and chromosomal localization of the human cGMP- binding cGMP-specific phosphodiesterase PDE5A gene.

1 Publications of Boster PDE5A Antibodies & ELISA Kits

PubMed ID: 10.1016/j.acthis.2018.03.002, An immunohistochemical and ultrastructural analysis of the retina in tadalafil (...

*More publications can be found for each product on its corresponding product page