This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PDE4D Antibodies
AND PDE4D ELISA kits, PDE4D Proteins
Many biological assays use antibodies to detect PDE4D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE4D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE4D antibodies...
Previous: CBLIF
Next: PDE6D
PDE4D Infographic by Boster Bio
All PDE4D Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, ICC, WB
$370
Cat # A01111-1
100 μg/vial
Cat # A01111-1
100 μg/vial
Human
Flow Cytometry
$515
Cat # A01111-Dyl488
100 μg/vial
Cat # A01111-Dyl488
100 μg/vial
Human
Flow Cytometry
$515
Cat # A01111-Dyl550
100 μg/vial
Cat # A01111-Dyl550
100 μg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1446
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1446
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2104
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2104
1 kit, containing two 96-well plates and all necessary reagents
PDE4D Overview
Facts about cAMP-specific 3',5'-cyclic phosphodiesterase 4D.
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (PDE4D)
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE4D |
| Uniprot: | Q08499 |
| Entrez: | 5144 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E3); cAMP-specific 3'-5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; DKFZp686M11213; Drosophila); dunce-like phosphodiesterase E3; EC 3.1.4; FLJ97311; HSPDE4D; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog; phosphodiesterase 4D, cAMP-specific
Molecular Weight
Mass (kDA):
91.115 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2-q12.1 |
| Sequence: | 5; NC_000005.10 (58969038..60524329, complement) |
Tissue Specificity
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Subcellular Localizations
Apical cell membrane. Cytoplasm. Membrane. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells.
Diseases
- Cerebrovascular Accident
- Ischemic Stroke
- Brain Ischemia
- Asthma
- Inflammation
- Lung Diseases
- Chronic Obstructive Airway Disease
- Hypertensive Disease
- Lung Diseases, Obstructive
- Vomiting
- Atherosclerosis
- Depressive Disorder
- Infarction
Interacting Proteins
- Adcy2
- ARRB2
- COIL
- GOLGA8DP
- GOLGA8F
- MAGEA6
- TRAF1
- ZDHHC17
Pathways
- Pathogenesis
- Localization
- Secretion
- Immune Response
- Inflammatory Response
- Reverse Transcription
- Mrna Splicing
- Cognition
- Cell Proliferation
- Ovulation
- Translation
- Cell Adhesion
- Long-term Memory
PTMs
- Phosphorylation
- Cleavage
- Sumoylation
- Nitrosylation
- Reduction
- Hydroxylation
Research Areas
- Lipid and Metabolism
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE4D
bosterbio.com/bosterbio-gene-info-cards/PDE4D
References
PMID: 8413254 by Bolger G., et al. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
PMID: 8797812 by Nemoz G., et al. Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells.