PCSK5 Antibodies

AND PCSK5 ELISA kits, PCSK5 Proteins

Many biological assays use antibodies to detect PCSK5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCSK5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCSK5 antibodies...

We validate the specificity of these antibodies to PCSK5 by testing them on tissues known to express PCSK5 positively and negatively. Browse below to find the PCSK5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCSK5 Infographic by Boster Bio

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PC6 (PCSK5) (NM_006200) Human Over-expression Lysate

Human

$628
Cat # LS005125
100 µg

PCSK5 Overview

Facts about Proprotein convertase subtilisin/kexin type 5.

PCSK5 3D structure. Source: alphafold

Proprotein convertase subtilisin/kexin type 5 (PCSK5)

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Probably functions in the constitutive and regulated secretory pathways.

Plays an important role in pregnancy establishment by proteolytic activation of a number of important factors like BMP2, CALD1 and alpha-integrins. .

Gene Information

Human
Gene Name:	PCSK5
Uniprot:	Q92824
Entrez:	5125

Family

Belongs to:

peptidase S8 family

Alternative Names

EC 3.4.21; EC 3.4.21.-; EC 3.4.21.61; EC 3.4.21.75; FLJ11149; FLJ16215; hPC6; PC5PC6A; PC6prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; proprotein convertase PC5; proprotein convertase subtilisin/kexin type 5; protease PC6; SPC6; Subtilisin/kexin-like protease PC5

Molecular Weight

Mass (kDA):
206.942 kDA

Genomic Context


Human

Location:	9q21.13
Sequence:	9; NC_000009.12 (75890644..76362975)

Tissue Specificity

Expressed in T-lymphocytes.

Subcellular Localizations

[Isoform PC6A]: Secreted. Secreted through the regulated secretory pathway.; [Isoform PC6B]: Endomembrane system; Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.

Diseases

Caudal Regression Syndrome
Cardiovascular Diseases
Congenital Absence
Tissue Adhesions
Limb Deformities, Congenital
Atresia
Endometrial Polyp
Sequelae Aspects
Coronary Artery Disease
Congenital Exomphalos
Rectal Fistula
Congenital Heart Defects

Tumor Angiogenesis
Hemorrhage
Pathologic Fistula
Vascular Stiffness
Dental Plaque
Anus, Imperforate
Congenital Abnormality

Interacting Proteins

GLRX3
KRTAP10-7
KRTAP10-8
KRTAP4-12
KRTAP5-9

LCE1D
LCE2C
LCE3C
MEOX2
NOTCH2NL

NUFIP2
POU4F2
STK16

Pathways

Ovarian Follicle Development
Secretory Pathway
Transport
Cell Adhesion
Aging
Proteolysis
Immune Response
Dna Methylation
Ovulation
Ossification
Energy Homeostasis
Localization
Neuromast Deposition

Embryo Development
Methylation
Swimming
Cell Growth
Regulation Of Angiogenesis
Angiogenesis
Invasive Growth

PTMs

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCSK5

References

PMID: 8755538 by Miranda L., et al. Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes.

PMID: 19764806 by Kilpatrick L.M., et al. Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment.