PCGF2 Antibodies

AND PCGF2 ELISA kits, PCGF2 Proteins

Many biological assays use antibodies to detect PCGF2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCGF2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCGF2 antibodies...

We validate the specificity of these antibodies to PCGF2 by testing them on tissues known to express PCGF2 positively and negatively. Browse below to find the PCGF2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCGF2 Infographic by Boster Bio

All PCGF2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PCGF2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05952
100ul

Mel18 (PCGF2) (NM_007144) Human Over-expression Lysate

Human

$628
Cat # LS007703
100 µg

PCGF2 Overview

Facts about Polycomb group RING finger protein 2.

PCGF2 3D structure. Source: alphafold

Polycomb group RING finger protein 2 (PCGF2)

Transcriptional repressor. Has tumor suppressor activity.

May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1.

Gene Information

Human
Gene Name:	PCGF2
Uniprot:	P35227
Entrez:	7703

Family

Belongs to:

No superfamily

Alternative Names

MEL-18; polycomb group ring finger 2; polycomb group RING finger protein 2; RING finger protein 110DNA-binding protein Mel-18; RNF110MEL18; Zinc finger protein 144; ZNF144MGC10545

Molecular Weight

Mass (kDA):
37.788 kDA

Genomic Context


Human

Location:	17q12
Sequence:	17; NC_000017.11 (38733898..38749817, complement)

Tissue Specificity

Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cell Transformation, Neoplastic
Carcinoma
Carcinogenesis
Neoplasm Metastasis
Malignant Paraganglionic Neoplasm
Stomach Neoplasms
Metastatic Malignant Neoplasm To The Lymph Node
Melanoma

Lymphoma
Medulloblastoma
Prostatic Neoplasms
Bone Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Stomach
Adenoma

Interacting Proteins

CBX6
CBX7
CBX8
MOV10
PHC1

PHC2
RING1
RNF2
UBC
USP11

USP7

Pathways

Cell Cycle
Cell Proliferation
Oncogenesis
Tube Formation
Mitosis
Localization
Cell Growth
Pathogenesis
Rna Interference
Cell Migration
Gene Silencing
Aging
Fibroblast Proliferation

Regulation Of Gene Expression
Chromosome Segregation
Cell Cycle Arrest
Paraxial Mesoderm Development
Cell Division
Mrna Transcription
Prophase

PTMs

Sumoylation

Phosphorylation

Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCGF2

References

PMID: 8325509 by Ishida A., et al. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif.

PMID: 19636380 by Maertens G.N., et al. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.