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Protocadherin-15 Antibodies
AND Pcdh15 ELISA kits, Protocadherin-15 Proteins
Many biological assays use antibodies to detect Protocadherin-15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protocadherin-15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protocadherin-15 antibodies...
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Pcdh15 Infographic by Boster Bio
All Pcdh15 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A03591-1
100 μg/vial
Cat # A03591-1
100 μg/vial
Human, Mouse, Rat
WB
$523
Cat # M03591
100 µl
Cat # M03591
100 µl
Pcdh15 Overview
Facts about Protocadherin-15.
Protocadherin-15 (Pcdh15)
Calcium-dependent cell-adhesion protein. Required for internal ear neuroepithelial cell elaboration and cochlear function.
Probably involved in the maintenance of normal retinal function. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pcdh15 |
| Uniprot: | Q99PJ1 |
| Entrez: | 11994 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
autosomal recessive 23; cadherin-related family member 15; CDHR15; DFNB23; DKFZp667A1711; PCDH15; Protocadherin15; Protocadherin-15; protocadherin-related 15; USH1F
Molecular Weight
Mass (kDA):
214.738 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10 B5.3|10 37.43 cM |
| Sequence: | 10; |
Tissue Specificity
Expressed in brain and sensory epithelium of the developing inner ear. Expressed in the retina, in the photoreceptor inner segments, the outer plexiform layer, the inner nuclei layer and the ganglion cell layer and, more diffusely in the inner plexiform layer (at protein level). Not detected in the retinal pigment epithelium (at protein level). Expressed in the spleen, dorsal root ganglion, dorsal aspect of neural tube, floor plate and ependymal cells adjacent to the neural canal.
Diseases
- Usher Syndrome
- Complete Hearing Loss
- Retinitis Pigmentosa
- Sensorineural Hearing Loss (disorder)
- Retinal Degeneration
- Tissue Adhesions
- Deafness Congenital
- Usher Syndrome, Type I
- Vestibular Diseases
- Retinal Diseases
- Blind Vision
- Nervousness
Pathways
- Localization
- Pathogenesis
- Transport
- Cell-cell Adhesion
- Cell Development
- Cell Adhesion
- Inner Ear Development
- Swimming
- Translation
- Ear Development
- Cell Migration
- Inner Ear Morphogenesis
- Photoreceptor Cell Maintenance
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pcdh15
bosterbio.com/bosterbio-gene-info-cards/Pcdh15
References
PMID: 11138007 by Alagramam K.N., et al. The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene.
PMID: 16799054 by Haywood-Watson R.J. II, et al. Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.