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- Table of Contents
Facts about Paired box protein Pax-8.
Human | |
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Gene Name: | PAX8 |
Uniprot: | Q06710 |
Entrez: | 7849 |
Belongs to: |
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No superfamily |
paired box 8; paired box gene 8; paired box protein Pax-8; paired domain gene 8
Mass (kDA):
48.218 kDA
Human | |
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Location: | 2q14.1 |
Sequence: | 2; NC_000002.12 (113215997..113278921, complement) |
Expressed in the excretory system, thyroid gland and Wilms tumors.
Nucleus.
If you're looking for a monoclonal antibody to detect the Renal Cell Marker PAX8, you've come to the right place. This Boster Bio review will cover what you should know about this product, the Boster Bio Incubation With ECL Kit, and the benefits of using the PAX8 marker. Then, you can submit your results using the Boster Bio online submission service. You'll also get product credits for any results you submit. And it's applicable to all scientists, not just those in the United States.
Boster Bio has recently released a PAX8 monoclonal antibody that reacts with the Renal Cell Marker protein. This antibody has been validated against human, mouse, rat, and pig tissues. This monoclonal antibody is available for purchase in the Picoband(tm) catalog. It stains over 90% of primary and metastatic renal cell carcinomas. It can also be used to confirm the diagnosis of patients with suspected renal cancer.
This product has a specific binding affinity to Ki67. Ki67 is a macro-molecular protein located in the nucleus of a cell. It consists of two peptide chains. Gerdes et al. prepared the Ki67 antibody in 1983 by using Huo Qijin lymphatic system IA28 nucleus and tissue culturing plate numbering 67.
This PAX8 monoclonal antibody has been shown to have superior sensitivity to PAX8 in renal, ovarian, and pancreatic cancers. The antibody has low to non-specific background staining. In addition, this antibody is highly consistent in its targeting of PAX8. Therefore, it is a highly suitable choice for research on patients with renal cancer and ovarian cancer.
PAX8 is a member of the PAX family of transcription factors and plays a crucial role in fetal development. It is necessary for kidney cell differentiation and thyroid development. PAX8 expression is found in up to 89% of tumor samples and is particularly frequent in ovarian and renal cell carcinomas. The product is available for purchase in the market.
The antigens used in the production of this monoclonal antibody are human colon cancer cell HT-29, breast cancer MDA-MB231 cell lines, and normal ovarian epithelial cells. The cells were cultured at 37degC in 5% CO2.
This relaxin neutralizing monoclonal antibody inhibits the growth of HGSOC cells by enhancing the cytotoxicity of cisplatin. The RLN1 and RLN2 have approximately 87% and 63% sequence identity, respectively. The antibody library was designed to identify clones that bind to RLN2 and neutralize cAMP induction in cell-based assays.
Angiogenesis is an essential process in the progression of renal cell carcinoma. The development of drugs that block angiogenesis has played a pivotal role in treating patients with metastatic RCC. However, these therapies often develop resistance, despite major advances in molecular understanding. Several new agents have been approved for this purpose, and are showing promising results in clinical trials.
The Boster Bio: Incubation with ECLE kit for PAX8 marker is a high-quality DNA ligation reagent. Using this kit will result in a clear color and a good signal intensity. Boster biotechnology products are widely used in scientific research. They have broad applications in the scientific community, including disease research, DNA manipulation, and investigation. The company provides comprehensive technical resources for researchers, including blogs, disease information, and web-based digital tools. The kit also features high-quality lysis buffers that reduce cross-linking intensity.
The PAX8 gene is a member of the pair-box family of transcription factor genes. It has been used to differentiate gynecological cancers from non-gynecologic malignancies, gastrointestinal cancers from breast cancers, and ovarian cancers from non-ovarian tumors. The PAX8 marker was recently used to separate ovarian cancer cells from non-ovarian tumors in a laboratory setting.
The PAX8 marker has shown superior sensitivity in detecting cancer cells. In cancer cell studies, it was shown to be highly sensitive for thyroid, ovarian, and renal cells. In addition, it had low sensitivity for cervical and bladder cancers, but had good sensitivity for pancreatic and neuroendocrine cells. For further research, PAX8 is an excellent way to distinguish between different types of gynecologic tumors.
PMID: 1337742 by Poleev A., et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors.
PMID: 8413205 by Kozmik Z., et al. Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.