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Paired box protein Pax-6 Antibodies
AND PAX6 ELISA kits, Paired box protein Pax-6 Proteins
Many biological assays use antibodies to detect Paired box protein Pax-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Paired box protein Pax-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Paired box protein Pax-6 antibodies...
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PAX6 Infographic by Boster Bio
All PAX6 Products
Product
Figures
Specificity
Applications
Price
Chicken, Human, Mouse, Rat
Flow Cytometry, IF, WB
$486
Cat # M00273-1
100ug/vial
Cat # M00273-1
100ug/vial
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # M00273-2
100 μl
Cat # M00273-2
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00273-3
100 μl
Cat # M00273-3
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A00273
100ul
Cat # A00273
100ul
PAX6 Overview
Facts about Paired box protein Pax-6.
Paired box protein Pax-6 (PAX6)
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity).
Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PAX6 |
| Uniprot: | P26367 |
| Entrez: | 5080 |
Family
| Belongs to: |
|---|
| paired homeobox family |
Alternative Names
keratitis); MGC17209; Oculorhombin; paired box 6; paired box protein Pax-6; Pax6
Molecular Weight
Mass (kDA):
46.683 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p13 |
| Sequence: | 11; NC_000011.10 (31784792..31817961, complement) |
Tissue Specificity
Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Subcellular Localizations
Nucleus.
Diseases
- Aniridia
- Nervousness
- Corneal Diseases
- Eye Abnormalities
- Neoplasms
- Hypoplasia
- Microphthalmos
- Haploinsufficiency
- Cataract
- Tissue Adhesions
- Diabetes Mellitus
- Malignant Neoplasms
Interacting Proteins
- Dynll1
- HOMER3
- Sumo1
Pathways
- Eye Development
- Neurogenesis
- Cell Proliferation
- Cell Differentiation
- Regeneration
- Cell Cycle
- Localization
- Brain Development
- Secretion
- Transdifferentiation
- Cell Migration
- Methylation
- Regionalization
PTMs
- Methylation
- Phosphorylation
- Cleavage
- Acetylation
- Ribosylation
Research Areas
- Cellular Markers
- Diabetes Research
- Neuroscience
- Sensory Systems
- Stem Cell Markers
- Transcription Factors and Regulators
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAX6
bosterbio.com/bosterbio-gene-info-cards/PAX6
References
PMID: 1684738 by Ton C.C.T., et al. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.
PMID: 1345175 by Glaser T., et al. Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene.