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- Table of Contents
Facts about Paired box protein Pax-6.
Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity).
Human | |
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Gene Name: | PAX6 |
Uniprot: | P26367 |
Entrez: | 5080 |
Belongs to: |
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paired homeobox family |
keratitis); MGC17209; Oculorhombin; paired box 6; paired box protein Pax-6; Pax6
Mass (kDA):
46.683 kDA
Human | |
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Location: | 11p13 |
Sequence: | 11; NC_000011.10 (31784792..31817961, complement) |
Fetal eye, brain, spinal cord and olfactory epithelium. Isoform 5a is less abundant than the PAX6 shorter form.
Nucleus.
PMID: 1684738 by Ton C.C.T., et al. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.
PMID: 1345175 by Glaser T., et al. Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene.