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- Table of Contents
Facts about PAS domain-containing serine/threonine-protein kinase.
Probably plays a role under changing environmental conditions (glucose, oxygen, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, resulting in GYS1 inactivation.
Human | |
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Gene Name: | PASK |
Uniprot: | Q96RG2 |
Entrez: | 23178 |
Belongs to: |
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protein kinase superfamily |
DKFZp434O051; EC 2.7.11.1; hPASK; KIAA0135DKFZp686P2031; PAS domain containing serine/threonine kinase; PAS-kinase; PASKINPAS domain-containing serine/threonine-protein kinase; PAS-serine/threonine kinase; STK37
Mass (kDA):
142.929 kDA
Human | |
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Location: | 2q37.3 |
Sequence: | 2; NC_000002.12 (241106099..241150264, complement) |
Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Present in germ cells of testis and in the midpiece of sperm tails (at protein level).
Cytoplasm. Nucleus. Localizes in the nucleus of testis germ cells and in the midpiece of sperm tails.
PMID: 11459942 by Rutter J., et al. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.
PMID: 9110174 by Yu W., et al. Large-scale concatenation cDNA sequencing.