Beta-parvin Antibodies

AND PARVB ELISA kits, Beta-parvin Proteins

Many biological assays use antibodies to detect Beta-parvin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-parvin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-parvin antibodies...

We validate the specificity of these antibodies to Beta-parvin by testing them on tissues known to express PARVB positively and negatively. Browse below to find the PARVB antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PARVB Infographic by Boster Bio

All PARVB Products

Product

Figures

Specificity

Applications

Price

Anti-Beta-parvin PARVB Antibody

1 Q&As

Human, Mouse, Rat

$405
Cat # A04707
100ul

Anti-PARVB Mouse Monoclonal Antibody [Clone ID: OTI1B9]

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M04707
100 µl

Anti-PARVB Mouse Monoclonal Antibody [Clone ID: OTI1B7]

Human, Mouse, Rat

IHC, WB

$523
Cat # M04707-1
100 µl

PARVB (NM_013327) Human Over-expression Lysate

Human

$628
Cat # LS029780
100 µg

PARVB Overview

Facts about Beta-parvin.

PARVB 3D structure. Source: alphafold

Beta-parvin (PARVB)

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia.

Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. .

Gene Information

Human
Gene Name:	PARVB
Uniprot:	Q9HBI1
Entrez:	29780

Family

Belongs to:

parvin family

Alternative Names

affixin; beta-parvin; CGI-56; parvin, beta

Molecular Weight

Mass (kDA):
41.714 kDA

Genomic Context


Human

Location:	22q13.31
Sequence:	22; NC_000022.11 (43999164..44172939)

Tissue Specificity

Expressed predominantly in heart and skeletal muscle.

Subcellular Localizations

Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line. Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.

Diseases

Tissue Adhesions
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Tumor Angiogenesis
Mammary Neoplasms
Bulla
Cell Invasion
Muscular Dystrophy
Diabetic Nephropathy
Weakness
Malignant Tumor Of Colon

Bone Neoplasms
Carcinogenesis
Carcinoma
Myopathy
Miyoshi Myopathy
Chondrosarcoma

Interacting Proteins

Arhgef6
Arhgef7

Pathways

Cell Adhesion
Cell Migration
Cell Growth
Cell Proliferation
Localization
Cell-matrix Adhesion
Cell-substrate Adhesion
Angiogenesis
Regulation Of Cell Adhesion
Cellular Senescence
Dna Methylation
Cellular Process
Platelet Aggregation

Dendritic Cell Migration
Senescence
Methylation
Cytoskeleton Organization
Stem Cell Proliferation
Cell Motility
Cell Differentiation

PTMs

Phosphorylation

Methylation

Ubiquitination

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARVB

References

PMID: 11402068 by Yamaji S., et al. A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.

PMID: 11171322 by Olski T.M., et al. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily.