Pappalysin-1 Antibodies

AND PAPPA ELISA kits, Pappalysin-1 Proteins

Many biological assays use antibodies to detect Pappalysin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pappalysin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pappalysin-1 antibodies...

We validate the specificity of these antibodies to Pappalysin-1 by testing them on tissues known to express PAPPA positively and negatively. Browse below to find the PAPPA antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: PAX7

PAPPA Infographic by Boster Bio

All PAPPA Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-PAPP A/PAPPA Antibody Picoband®

3 Q&As

Human

IHC, WB

$370
Cat # PB9306
100 μg/vial

Anti-PAPP-A Antibody (Monoclonal, ABM4C62)

1 Q&As

Human

IHC

$366
Cat # M06838
100 µg

Anti-PAPP1 PAPPA Antibody

Human, Mouse

ELISA, WB

$380
Cat # A04283
100ul

PAPP A (PAPPA) (NM_002581) Human Recombinant Protein

$1249
Cat # PROTQ13219
20 µg

PAPPA Overview

Facts about Pappalysin-1.

PAPPA 3D structure. Source: alphafold

Pappalysin-1 (PAPPA)

Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.

Gene Information

Human
Gene Name:	PAPPA
Uniprot:	Q13219
Entrez:	5069

Family

Belongs to:

peptidase M43B family

Alternative Names

ASBABP2; DIPLA1; EC 3.4.24.79; IGFBP-4ase; IGFBP-4aseaspecific BCL2 ARE-binding protein 2; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; Insulin-like growth factor-dependent IGF-binding protein 4 protease; PAPA; PAPPA; PAPPA1; PAPP-A1; PAPP-Adifferentially placenta 1 expressed protein; Pappalysin1; Pappalysin-1; pregnacy-associated plasma protein A; Pregnancy-associated plasma protein A; pregnancy-associated plasma protein A, pappalysin 1

Molecular Weight

Mass (kDA):
180.973 kDA

Genomic Context


Human

Location:	9q33.1
Sequence:	9; NC_000009.12 (116153752..116402321)

Tissue Specificity

High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts.

Subcellular Localizations

Secreted.

Diseases

Malignant Neoplasms
Pre-eclampsia
Neoplasms
Pregnancy Complications
Down Syndrome
Hypertension Induced By Pregnancy
Ovarian Neoplasm
Malignant Neoplasm Of Ovary
Cell Invasion
Hypertensive Disease
Cholangiocarcinoma
Neoplasm Metastasis

Disease Of Adrenal Medulla
Hypoxia
Aneuploidy
Neoplasm Invasiveness
Infertility
Malignant Tumor Of Cervix
Carcinoma

Pathways

Proteolysis
Aging
Cell Adhesion
Cell Activation
T Cell Activation
Protein Secretion
Ossification
System Process
Cytoskeleton Organization
Tissue Development
Translation
Cell Differentiation
Bone Development

Actin Cytoskeleton Organization
Cell Proliferation
Immune System Process
Parturition
Glycosylation
Ovulation
Localization

PTMs

Cleavage

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAPPA

References

PMID: 8620868 by Haaning J., et al. Complete cDNA sequence of the preproform of human pregnancy- associated plasma protein-A. Evidence for expression in the brain and induction by cAMP.

PMID: 7508748 by Kristensen T., et al. Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA.