Poly(A) polymerase alpha Antibodies

AND PAPOLA ELISA kits, Poly(A) polymerase alpha Proteins

Many biological assays use antibodies to detect Poly(A) polymerase alpha, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Poly(A) polymerase alpha in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Poly(A) polymerase alpha antibodies...

We validate the specificity of these antibodies to Poly(A) polymerase alpha by testing them on tissues known to express PAPOLA positively and negatively. Browse below to find the PAPOLA antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PAPOLA Infographic by Boster Bio

All PAPOLA Products

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Anti-Poly(A) polymerase alpha PAPOLA Antibody

Human, Mouse, Rat

$405
Cat # A08667
100ul

PAPOLA (NM_032632) Human Over-expression Lysate

Human

$628
Cat # LS010914
100 µg

PAPOLA Overview

Facts about Poly(A) polymerase alpha.

PAPOLA 3D structure. Source: alphafold

Poly(A) polymerase alpha (PAPOLA)

Polymerase that produces the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites.

May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. .

Gene Information

Human
Gene Name:	PAPOLA
Uniprot:	P51003
Entrez:	10914

Family

Belongs to:

poly(A) polymerase family

Alternative Names

EC 2.7.7; EC 2.7.7.19; PAP-alpha; PAPMGC5378; poly(A) polymerase alpha; Polynucleotide adenylyltransferase alpha

Molecular Weight

Mass (kDA):
82.843 kDA

Genomic Context


Human

Location:	14q32.2
Sequence:	14; NC_000014.9 (96502376..96567116)

Subcellular Localizations

Cytoplasm. Nucleus. The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.

PTMs

Acetylation
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAPOLA

References

PMID: 8302877 by Thuresson A.-C., et al. Multiple forms of poly(A) polymerases in human cells.

PMID: 15169763 by Dettwiler S., et al. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.