PABPN1 Antibodies

AND PABPN1 ELISA kits, PABPN1 Proteins

Many biological assays use antibodies to detect PABPN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PABPN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PABPN1 antibodies...

We validate the specificity of these antibodies to PABPN1 by testing them on tissues known to express PABPN1 positively and negatively. Browse below to find the PABPN1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PABPN1 Infographic by Boster Bio

All PABPN1 Products

Product

Figures

Specificity

Applications

Price

Anti-PABPN1 Rabbit Monoclonal Antibody

6 Q&As

Human, Mouse

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M02445
100 μl

Anti-PABPN1 Antibody

Human, Mouse

$405
Cat # A02445
100ul

Anti-PABPN1 Antibody

Human, Mouse

Flow Cytometry, IP, IF, IHC, ICC, WB

$405
Cat # A02445-1
100ul

Human PABPN1 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ86U42
Starting from 20ug

PABPN1 Overview

Facts about Polyadenylate-binding protein 2.

PABPN1 3D structure. Source: alphafold

Polyadenylate-binding protein 2 (PABPN1)

Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation response and controls the poly(A) tail length (By similarity).

Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense- mediated decay (NMD) of mRNA.

Gene Information

Human
Gene Name:	PABPN1
Uniprot:	Q86U42
Entrez:	8106

Family

Belongs to:

No superfamily

Alternative Names

Nuclear poly(A)-binding protein 1; OPMD; PAB2poly(A) binding protein II; PABII; PABP-2; PABP2polyadenylate-binding protein 2; poly(A) binding protein 2; poly(A) binding protein, nuclear 1; Poly(A)-binding protein 2; Poly(A)-binding protein II; poly(A)-binding protein, nuclear 1; Polyadenylate-binding nuclear protein 1

Molecular Weight

Mass (kDA):
32.749 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (23320188..23326185)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus. Cytoplasm. Nucleus speckle. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus (PubMed:10688363). Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism (By similarity). Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). Intranuclear filamentous inclusions or 'aggregates' are detected in the myo