P2X purinoceptor 7 Antibodies

AND P2RX7 ELISA kits, P2X purinoceptor 7 Proteins

Many biological assays use antibodies to detect P2X purinoceptor 7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with P2X purinoceptor 7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop P2X purinoceptor 7 antibodies...

We validate the specificity of these antibodies to P2X purinoceptor 7 by testing them on tissues known to express P2RX7 positively and negatively. Browse below to find the P2RX7 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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P2RX7 Infographic by Boster Bio

All P2RX7 Products

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Product

Figures

Specificity

Applications

Price

Anti-P2X purinoceptor 7 P2RX7 Antibody Picoband®

6 Q&As

Human, Mouse, Rat

$370
Cat # PA2129
100 μg/vial

Anti-P2X purinoceptor 7 P2RX7 Antibody

1 Citations

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A01208
0.1 mg

Anti-P2X purinoceptor 7 P2RX7 Antibody

1 Citations

Mouse, Rat

$405
Cat # A01208-1
100ul

Anti-P2RX7 Antibody Picoband®

Mouse

ELISA, WB

$370
Cat # A01208-2
100 μg/vial

Anti-P2X7/P2RX7 Antibody Picoband®

1 Citations

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01208-3
100 μg/vial

P2RX7 (NM_002562) Human Over-expression Lysate

Human

$960
Cat # LS005027
100 µg

P2RX7 Overview

Facts about P2X purinoceptor 7.

P2RX7 3D structure. Source: alphafold

P2X purinoceptor 7 (P2RX7)

Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules.

Could operate in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).

Gene Information

Human
Gene Name:	P2RX7
Uniprot:	Q99572
Entrez:	5027

Family

Belongs to:

P2X receptor family

Alternative Names

ATP receptor; MGC20089; P2RX7; P2X purinoceptor 7; P2X7; P2X7P2X7 receptor; P2X7R; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7; purinergic receptor P2X7 variant A; Purinergic receptor

Molecular Weight

Mass (kDA):
68.585 kDA

Genomic Context


Human

Location:	12q24.31
Sequence:	12; NC_000012.12 (121132819..121188032)

Tissue Specificity

Widely expressed with highest levels in brain and immune tissues.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Inflammation
Pain
Nervousness
Chronic Lymphocytic Leukemia
Leukemia
Malignant Neoplasms
Lymphoid Leukemia
Tuberculosis
Depressive Disorder
Bipolar Disorder
Neoplasms
Mood Disorders
Arthritis

Inflammatory Response
Ischemia
Major Depressive Disorder
Neuralgia
Rheumatoid Arthritis
Autoimmune Reaction
Nerve Degeneration

Pathways

Cell Death
Secretion
Localization
Pathogenesis
Immune Response
Response To Atp
Inflammatory Response
Cell Proliferation
Transport
Cytokine Production
Synaptic Transmission
Membrane Depolarization
Innate Immune Response

Exocytosis
Cell Cycle
Cell Growth
Cytolysis
Neuroprotection
Regeneration
Induction Of Apoptosis

PTMs

Phosphorylation
Cleavage
Ribosylation
Dephosphorylation
Glycosylation
Oxidation

Biotinylation
Nitration
Reduction
Deamination
Gpi Anchoring
Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/P2RX7

References

PMID: 9038151 by Rassendren F., et al. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA.

PMID: 9826911 by Buell G.N., et al. Gene structure and chromosomal localization of the human P2X7 receptor.

2 Publications of Boster P2X purinoceptor 7 Antibodies & ELISA Kits

PubMed ID: 10.1016/j.clineuro.2017.04.012, Increased expression of P2X7 receptor in peripheral blood mononuclear cells corr...
PubMed ID: 32783373, Zou Z,Wang Q,Zhou M,Li W,Zheng Y,Li F,Zheng S,He Z.Protective effects of P2X7R a...

*More publications can be found for each product on its corresponding product page