Proton channel OTOP1 Antibodies

AND Otop1 ELISA kits, Proton channel OTOP1 Proteins

Many biological assays use antibodies to detect Proton channel OTOP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proton channel OTOP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proton channel OTOP1 antibodies...

We validate the specificity of these antibodies to Proton channel OTOP1 by testing them on tissues known to express Otop1 positively and negatively. Browse below to find the Otop1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Otop1 Infographic by Boster Bio

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Otop1 Overview

Facts about Proton channel OTOP1.

Proton channel OTOP1 (Otop1)

Proton-selective channel that specifically transports protons into cells (PubMed:29371428). Proton channel activity is only weakly-sensitive to voltage (PubMed:29371428).

Proton- selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428). In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (PubMed:12651873).

Gene Information

Mouse
Gene Name:	Otop1
Uniprot:	Q80VM9
Entrez:	21906

Family

Belongs to:

otopetrin family

Alternative Names

MGC163302; MGC163304; otopetrin 1; otopetrin-1

Molecular Weight

Mass (kDA):
65.755 kDA

Genomic Context


Mouse

Location:	5 B3\|5 20.35 cM
Sequence:	5;

Tissue Specificity

Detected in embryonic inner ear macular epithelia (PubMed:12651873). Expressed in thymus, heart, kidney, skin, vestibular system of the inner ear, sour taste cells, brown adipose tissue, heart, uterus, dorsal root ganglion, adrenal gland, lactating mammary gland and stimulated mast cells (PubMed:12651873, PubMed:29371428). Specifically expressed in sour taste cells and not other types of taste cells (PubMed:29371428).

Diseases

Congenital Absence
Usher Syndrome
Osteosarcoma
Complete Hearing Loss
Equilibration Disorder
Vertigo
Impairment (finding)
Macule

Benign Paroxysmal Positional Vertigo
Vestibular Diseases
Vertigo Positional

Pathways

Endoderm Formation
Otolith Formation
Gastrulation
Response To Atp
Localization

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Otop1

References

PMID: 12651873 by Hurle B., et al. Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1.

PMID: 17606897 by Hughes I., et al. Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium.