ORC1 Antibodies

AND ORC1 ELISA kits, ORC1 Proteins

Many biological assays use antibodies to detect ORC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ORC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ORC1 antibodies...

We validate the specificity of these antibodies to ORC1 by testing them on tissues known to express ORC1 positively and negatively. Browse below to find the ORC1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ORC1 Infographic by Boster Bio

All ORC1 Products

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Product

Figures

Specificity

Applications

Price

Anti-ORC1 Antibody

5 Q&As

Human

$399
Cat # A02735
100μl

Anti-ORC1 Antibody

Human, Mouse, Rat

$405
Cat # A02735-1
100ul

Anti-ORC1 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02735-2
100 μg/vial

ORC1 (NM_004153) Human Over-expression Lysate

Human

$628
Cat # LS004998
100 µg

ORC1 Overview

Facts about Origin recognition complex subunit 1.

ORC1 3D structure. Source: alphafold

Origin recognition complex subunit 1 (ORC1)

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.

The DNA sequences that define origins of replication haven't been identified yet. ORC is required to assemble the pre-replication complex required to initiate DNA replication.

Gene Information

Human
Gene Name:	ORC1
Uniprot:	Q13415
Entrez:	4998

Family

Belongs to:

ORC1 family

Alternative Names

HS; HSORC1; ORC1Lorigin recognition complex subunit 1; origin recognition complex, subunit 1 (yeast homolog)-like; origin recognition complex, subunit 1 homolog (S. cerevisiae); origin recognition complex, subunit 1 homolog; origin recognition complex, subunit 1; origin recognition complex, subunit 1-like (yeast); origin recognition complex, subunit 1-like; PARC1origin recognition complex 1; Replication control protein 1

Molecular Weight

Mass (kDA):
97.35 kDA

Genomic Context


Human

Location:	1p32.3
Sequence:	1; NC_000001.11 (52372829..52404471, complement)

Subcellular Localizations

Nucleus.

Diseases

Ear, Patella, Short Stature Syndrome
Dwarfism
Micrognathism
Growth Disorders
Malignant Neoplasms
Microcephaly
Neoplasms
Endoreduplication
Malaria, Falciparum
Aneuploidy
Malaria
Genomic Instability

Aortic Aneurysm, Abdominal
Growth Retardation
Retinoblastoma
Seckel Syndrome
African Trypanosomiasis
Hypoplasia
Hyperammonemia

Interacting Proteins

ORC2
ORC3
ORC5
SKP2
TERF2

Pathways

Dna Replication
Cell Cycle
S Phase
Mitosis
Localization
Dna Replication Initiation
Cell Division
M Phase
Cell Proliferation
Gene Silencing
G1 Phase
Cell Growth
Proteolysis

Methylation
Metaphase
Cytokinesis
Transport
Dna Repair
Pathogenesis
Hyperphosphorylation

PTMs

Phosphorylation
Acetylation
Methylation

Ubiquitination
Dephosphorylation
Cleavage

Deacetylation

Research Areas

Cancer
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORC1

References

PMID: 7502077 by Gavin K.A., et al. Conserved initiator proteins in eukaryotes.

PMID: 9566895 by Saha P., et al. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.