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- Table of Contents
, No Gclids
Optineurin Antibodies
AND OPTN ELISA kits, Optineurin Proteins
Many biological assays use antibodies to detect Optineurin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Optineurin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Optineurin antibodies...
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OPTN Infographic by Boster Bio
All OPTN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PB9343
100 μg/vial
Cat # PB9343
100 μg/vial
Human, Mouse, Rat
WB
$370
Cat # M00952
100 μg/vial
Cat # M00952
100 μg/vial
Human
IHC, WB
$523
Cat # M00952-1
100 µl
Cat # M00952-1
100 µl
OPTN Overview
Facts about Optineurin.
Optineurin (OPTN)
Plays an essential part in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8 (PubMed:27534431). Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation (PubMed:27534431).
Mechanistically, recruits TBK1 in the Golgi apparatus, boosting its trans-phosphorylation after RLR or TLR3 stimulation (PubMed:27538435). In turn, triggered TBK1 phosphorylates its downstream partner IRF3 to generate IFN-beta.
Gene Information
| Human | |
|---|---|
| Gene Name: | OPTN |
| Uniprot: | Q96CV9 |
| Entrez: | 10133 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FIP2FIP-2; GLC1Eglaucoma 1, open angle, E (adult-onset); HIP7ALS12; Huntingtin interacting protein L; Huntingtin yeast partner L; Huntingtin-interacting protein 7; Huntingtin-interacting protein L; HYPLHIP-7; NEMO-related protein; NRPE3-14.7K-interacting protein; Optic neuropathy-inducing protein; optineurin; TFIIIA-INTP; Transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucinezipper domains
Molecular Weight
Mass (kDA):
65.922 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p13 |
| Sequence: | 10; NC_000010.11 (13100082..13138308) |
Tissue Specificity
Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
Subcellular Localizations
Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy.
Diseases
- Glaucoma
- Glaucoma, Open-angle
- Primary Open Angle Glaucoma
- Intraocular Pressure Disorder
- Amyotrophic Lateral Sclerosis
- Sclerosis
- Primary Lateral Sclerosis
- Liver Diseases
- Decreased Immunologic Activity [pe]
- Low Tension Glaucoma
- Graft Failure
- Blind Vision
Interacting Proteins
- AKAP6
- CDC23
- DAZAP2
- DST
- DYSF
- HACE1
- HTT
- LITAF
- MPP1
- RAB10
Pathways
- Pathogenesis
- Localization
- Cell Death
- Sensitization
- Secretion
- Autophagy
- Transport
- Immune Response
- Rna Interference
- Aging
- Response To Oxidative Stress
- Cell Division
- Innate Immune Response
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Immunology
- Innate Immunity
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OPTN
bosterbio.com/bosterbio-gene-info-cards/OPTN
References
PMID: 9488477 by Li Y., et al. Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.
PMID: 11834836 by Rezaie T., et al. Adult-onset primary open-angle glaucoma caused by mutations in optineurin.