Nociceptin receptor Antibodies

G-protein coupled opioid receptor that functions as receptor to the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling through G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases.