Delta-type opioid receptor (OPRD1)

G-protein coupled receptor that acts as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that activates signaling through guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.

Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.