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- Table of Contents
Facts about Melanopsin.
Might be able to isomerize covalently bound all- trans retinal back to 11-cis retinal. .
Mouse | |
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Gene Name: | Opn4 |
Uniprot: | Q9QXZ9 |
Entrez: | 30044 |
Belongs to: |
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G-protein coupled receptor 1 family |
melanopsin; MGC142118; MOP; opsin 4
Mass (kDA):
57.231 kDA
Mouse | |
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Location: | 14|14 B |
Sequence: | 14; |
Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina. Isoform 2 is about 40 times more abundant than isoform 1 in the retina. Isoform 1 is observed with processes in the outer strata of inner plexiform layer (IPL) close to the inner nuclear layer (INL) or is found to be bistratified with processes located both in the inner (ON) or outer (OFF) layers of the IPL. A second population of isoform 1 is identified in processes which are confined to the inner layer of the IPL near to the ganglion cell layer (GCL). Isoform 2 is involved in processes localized to the outer IPL or is bistratified with processes in both the inner and outer layers of the IPL. Isoform 2 is absent in the processes confined only to the inner layer of the IPL.
PMID: 10632589 by Provencio I., et al. A novel human opsin in the inner retina.
PMID: 19793992 by Pires S.S., et al. Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina.