2'-5'-oligoadenylate synthase 3 (OAS3)

Interferon-induced, dsRNA-activated antiviral enzyme which plays a vital role in cellular innate antiviral response. Additionally, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation.

Synthesizes preferentially dimers of two'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) resulting in its dimerization and subsequent activation. Activation of RNase L contributes to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication.