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- Table of Contents
Facts about Cytosolic Fe-S cluster assembly factor NUBP1.
The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to goal apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity).
Human | |
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Gene Name: | NUBP1 |
Uniprot: | P53384 |
Entrez: | 4682 |
Belongs to: |
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Mrp/NBP35 ATP-binding proteins family |
cytosolic Fe-S cluster assembly factor NUBP1; MGC117406; MGC130053; NBP 1; NBP1; NBPMGC130052; nucleotide binding protein (e.coli MinD like); nucleotide binding protein 1 (E.coli MinD like); nucleotide binding protein 1 (MinD homolog, E. coli); Nucleotide-binding protein 1
Mass (kDA):
34.534 kDA
Human | |
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Location: | 16p13.13 |
Sequence: | 16; NC_000016.10 (10743164..10769351) |
Cytoplasm. Nucleus. Cell projection. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to
PMID: 7926816 by Shahrestanifar M., et al. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD.
PMID: 18573874 by Stehling O., et al. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.