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NTRK1 Antibodies
AND NTRK1 ELISA kits, NTRK1 Proteins
Many biological assays use antibodies to detect NTRK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NTRK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NTRK1 antibodies...
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NTRK1 Infographic by Boster Bio
All NTRK1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK0846
96 wells/kit, with removable strips.
Cat # EK0846
96 wells/kit, with removable strips.
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00706-1
100 μl
Cat # M00706-1
100 μl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00706
100 μl
Cat # M00706
100 μl
Human, Mouse, Rat
ELISA, WB
$380
Cat # A00706Y680Y681
100ul
Cat # A00706Y680Y681
100ul
NTRK1 Overview
Facts about High affinity nerve growth factor receptor.
High affinity nerve growth factor receptor (NTRK1)
Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous nerves. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338).
However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417).
Gene Information
| Human | |
|---|---|
| Gene Name: | NTRK1 |
| Uniprot: | P04629 |
| Entrez: | 4914 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
DKFZp781I14186; EC 2.7.10; EC 2.7.10.1; MTChigh affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; NTRK-1; p140-TrkA; TRK1-transforming tyrosine kinase protein; TrkA; Trk-A; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A
Molecular Weight
Mass (kDA):
87.497 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.1 |
| Sequence: | 1; NC_000001.11 (156815750..156881850) |
Tissue Specificity
Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Recycling endosome membrane; Single-pass type I membrane protein. Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at
Diseases
- Neoplasms
- Pain
- Thyroid Neoplasm
- Malignant Neoplasms
- Carcinoma
- Anhidrosis
- Hsan Type Iv
- Hereditary Sensory And Autonomic Neuropathies
- Malignant Neoplasm Of Thyroid
- Carcinoma, Papillary
- Papillary Thyroid Carcinoma
Interacting Proteins
- CBL
- NGF
- PTPN1
- SORT1
- SQSTM1
- ULK1
Pathways
- Pathogenesis
- Localization
- Innervation
- Cell Proliferation
- Dna Methylation
- Methylation
- Interphase
- Wound Healing
- Oncogenesis
- Dedifferentiation
- Neural Crest Cell Differentiation
- Cell Migration
- Gene Silencing
PTMs
- Phosphorylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NTRK1
bosterbio.com/bosterbio-gene-info-cards/NTRK1
References
PMID: 2927393 by Martin-Zanca D., et al. Molecular and biochemical characterization of the human trk proto- oncogene.
PMID: 7823156 by Shelton D.L., et al. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
2 Publications of Boster NTRK1 Antibodies & ELISA Kits
- PubMed ID: 21385399, Li Y, Zhang Sf, Zou Se, Xia X, Bao L. Reprod Biol Endocrinol. 2011 Mar 8;9:30. D...
- PubMed ID: 25042774, Li C, Ma Y, Yi K, Wang C, Li W, Liu Z, Sun L, Chen S, Yu J, Li H, Chen L, Zhou X...
*More publications can be found for each product on its corresponding product page