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NUP98 Antibodies
AND NUP98 ELISA kits, NUP98 Proteins
Many biological assays use antibodies to detect NUP98, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NUP98 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NUP98 antibodies...
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NUP98 Infographic by Boster Bio
All NUP98 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A01301-1
100 µg/vial
Cat # A01301-1
100 µg/vial
NUP98 Overview
Facts about Nuclear pore complex protein Nup98-Nup96.
Nuclear pore complex protein Nup98-Nup96 (NUP98)
Plays a role in the nuclear pore complex (NPC) assembly and/or upkeep. NUP98 and NUP96 are involved in the bidirectional transport across the NPC.
May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134).
Gene Information
| Human | |
|---|---|
| Gene Name: | NUP98 |
| Uniprot: | P52948 |
| Entrez: | 4928 |
Family
| Belongs to: |
|---|
| nucleoporin GLFG family |
Alternative Names
ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup98-Nup96; nucleoporin 98kD; nucleoporin 98kDa; NUP196; NUP96; Nup98-Nup96
Molecular Weight
Mass (kDA):
197.579 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.4 |
| Sequence: | 11; NC_000011.10 (3675010..3797554, complement) |
Subcellular Localizations
Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). Remains localized to the nuclear membrane after poliovirus (PV
Diseases
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Chromosomal Translocation
- Malignant Neoplasms
- Leukemogenesis
- Cell Transformation, Neoplastic
- Dysmyelopoietic Syndromes
- Myeloid Leukemia, Chronic
- Cytogenetic Abnormality
- Hematologic Neoplasms
- Neoplasms
Interacting Proteins
- RAE1
Pathways
- Transport
- Localization
- Nuclear Export
- Nuclear Transport
- Mitosis
- Nuclear Import
- Pathogenesis
- Nucleocytoplasmic Transport
- Cell Cycle
- Translation
- Metaphase
- Methylation
- Protein Import
PTMs
- Cleavage
- Phosphorylation
- Methylation
Research Areas
- Cancer
- Mitotic Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUP98
bosterbio.com/bosterbio-gene-info-cards/NUP98
References
PMID: 8563754 by Borrow J., et al. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.
PMID: 10087256 by Fontoura B.M.A., et al. A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.