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- Table of Contents
Facts about Cleavage and polyadenylation specificity factor subunit 5.
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Human | |
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Gene Name: | NUDT21 |
Uniprot: | O43809 |
Entrez: | 11051 |
Belongs to: |
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Nudix hydrolase family |
CFIm25; CFIM25CPSF 25 kDa subunit; cleavage and polyadenylation specific factor 5, 25 kD subunit; cleavage and polyadenylation specific factor 5, 25 kDa; Cleavage and polyadenylation specificity factor 25 kDa subunit; cleavage and polyadenylation specificity factor subunit 5; CPSF25; CPSF5DKFZp686H1588; Nucleoside diphosphate-linked moiety X motif 21; nudix (nucleoside diphosphate linked moiety X)-type motif 21; Nudix motif 21; pre-mRNA cleavage factor Im (25kD); Pre-mRNA cleavage factor Im 25 kDa subunit; pre-mRNA cleavage factor Im, 25kD subunit
Mass (kDA):
26.227 kDA
Human | |
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Location: | 16q13 |
Sequence: | 16; NC_000016.10 (56429133..56451332, complement) |
Expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm in a transcription- and XPO1/CRM1-independent manner, most probably in complex with the cleavage factor Im complex (CFIm) (PubMed:19864460). In punctate subnuclear structures localized adjacent to nuclear speckles, called paraspeckles (PubMed:15169763).
PMID: 9659921 by Rueegsegger U., et al. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits.
PMID: 8626397 by Rueegsegger U., et al. Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors.