Nsg1 Antibodies

AND Nsg1 ELISA kits, Nsg1 Proteins

Many biological assays use antibodies to detect Nsg1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nsg1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nsg1 antibodies...

We validate the specificity of these antibodies to Nsg1 by testing them on tissues known to express Nsg1 positively and negatively. Browse below to find the Nsg1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nsg1 Infographic by Boster Bio

All Nsg1 Products

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Product

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Specificity

Applications

Price

Anti-NEEP21 NSG1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$380
Cat # A12107
100ul

D4S234E (NSG1) (NM_014392) Human Over-expression Lysate

Human

$628
Cat # LS027065
100 µg

Anti-NSG1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A12107-1
100 µg/vial

Nsg1 Overview

Facts about Neuronal vesicle trafficking-associated protein 1.

Neuronal vesicle trafficking-associated protein 1 (Nsg1)

Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15187090, PubMed:12070131, PubMed:21084623, PubMed:16037816). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by changing the recycling and targeting of AMPA receptors to the synapse (PubMed:16037816).

Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis through the activation of CASP3 in response to DNA damage (By similarity).

Gene Information

Mouse
Gene Name:	Nsg1
Uniprot:	Q62092
Entrez:	18196

Family

Belongs to:

NSG family

Alternative Names

carboxyterminally EE-tagged neuron-enriched endosomal 21 kDa protein; D4S234Brain neuron cytoplasmic protein 1; DNA segment on chromosome 4 (unique) 234 expressed sequence; NEEP21; neuron-specific protein family member 1; NSG1; P21

Molecular Weight

Mass (kDA):
20.929 kDA

Genomic Context


Mouse

Location:	5 B3\|5 20.21 cM
Sequence:	5;

Tissue Specificity

Pituitary and less in adrenal gland and testis. Expressed in the hippocampus throughout development. At P0, highly and broadly expressed throughout the cortical plate, but is down-regulated overall at P8 and P14, but remains relatively enriched in layer V. At P0 is expressed ubiquitously in the developing cerebellum namely Purkinje neurons as well as granule neurons. However, it becomes restricted to Purkinje cells by P8. This exclusive expression in Purkinje cells is maintained throughout adulthood.

Diseases

Malignant Neoplasms
Neoplasms

Pathways

Chemotaxis
Cell Death
Cell Growth
Receptor Recycling

PTMs

Cleavage

Ubiquitination

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nsg1

References

PMID: 9013775 by Carlock L., et al. Variable subcellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons.

PMID: 9461575 by Saberan-Djoneidi D., et al. A 21-kDa polypeptide belonging to a new family of proteins is expressed in the Golgi apparatus of neural and germ cells.