Nsd1 Antibodies

AND Nsd1 ELISA kits, Nsd1 Proteins

Many biological assays use antibodies to detect Nsd1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nsd1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nsd1 antibodies...

We validate the specificity of these antibodies to Nsd1 by testing them on tissues known to express Nsd1 positively and negatively. Browse below to find the Nsd1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nsd1 Infographic by Boster Bio

All Nsd1 Products

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Specificity

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Price

Anti-NSD1/Kmt3B Monoclonal Antibody

3 Q&As

Human

$399
Cat # A02327
100μl

Anti-NSD1 Antibody

Human, Mouse

$405
Cat # A02327-1
100ul

Nsd1 Overview

Facts about Histone-lysine N-methyltransferase, H3 lysine-36 specific.

Histone-lysine N-methyltransferase, H3 lysine-36 specific (Nsd1)

Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro).

Transcriptional intermediary factor capable of influencing transcription. May also positively affect transcription.

Gene Information

Mouse
Gene Name:	Nsd1
Uniprot:	O88491
Entrez:	18193

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

Androgen receptor coactivator 267 kDa protein; Androgen receptor-associated protein of 267 kDa; ARA267STO; DKFZp666C163; EC 2.1.1.43; FLJ10684; FLJ22263; FLJ44628; H3 lysine-36 and H4 lysine-20 specific; KMT3BSotos syndrome; Lysine N-methyltransferase 3B; NR-binding SET domain-containing protein; nuclear receptor binding SET domain protein 1

Molecular Weight

Mass (kDA):
284.084 kDA

Genomic Context


Mouse

Location:	13\|13 B1
Sequence:	13;

Tissue Specificity

Expressed in the embryo and the outer region of the uterine decidua at early post-implantation E5.5 stage. Uniformly expressed in embryonic and extraembryonic tissues during gastrulation stage E7.5. Expressed differentially after stage 14.5 with highest expression in proliferating cells. Enriched in the telencephalic region of the brain, spinal cord, intestinal crypt, tooth buds, thymus and salivary glands at stage E16.5. Also expressed in the ossification region of developing bones and in the periosteum.

Diseases

Sotos' Syndrome
Growth Disorders
Haploinsufficiency
Craniofacial Abnormalities
Neoplasms
Macrocephaly
Malignant Neoplasms
Developmental Delay (disorder)
Gigantism
Leukemia
Developmental Disabilities

Leukemia, Myelocytic, Acute
Myeloid Leukemia
Weaver Syndrome
Congenital Heart Defects
Learning Disorders
Learning Disabilities

Pathways

Methylation
Pathogenesis
Histone Methylation
Histone Modification
Bone Development
Dna Methylation
Localization
Transport
Brain Development
Mesoderm Formation
Dosage Compensation
Cell Cycle Arrest
Tooth Eruption

Translation
Cell Cycle
Histone Acetylation
Bone Morphogenesis
Histone Lysine Methylation
Mrna Processing
Oncogenesis

PTMs

Methylation
Phosphorylation

Acetylation
Demethylation

Research Areas

Apoptosis
Breast Cancer
Cancer
Cellular Markers
Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nsd1

References

PMID: 9628876 by Huang N., et al. Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.

PMID: 12805229 by Rayasam G.V., et al. NSD1 is essential for early post-implantation development and has a catalytically active SET domain.