NRL Antibodies

AND NRL ELISA kits, NRL Proteins

Many biological assays use antibodies to detect NRL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NRL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NRL antibodies...

We validate the specificity of these antibodies to NRL by testing them on tissues known to express NRL positively and negatively. Browse below to find the NRL antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NRL Infographic by Boster Bio

All NRL Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-NRL Antibody

Human

$360
Cat # A00505
100 µl

Anti-Nrl Antibody

7 Q&As

Human, Mouse

$399
Cat # A00505-1
100μl

Anti-NRL Antibody

Human, Mouse, Rat

$405
Cat # A00505-2
100ul

Anti-NRL Mouse Monoclonal Antibody [Clone ID: OTI5H2]

Human, Mouse, Rat

$523
Cat # M00505
100 µl

NRL (NM_006177) Human Over-expression Lysate

Human

$628
Cat # LS004901
100 µg

NRL Overview

Facts about Neural retina-specific leucine zipper protein.

NRL 3D structure. Source: alphafold

Neural retina-specific leucine zipper protein (NRL)

Acts as a transcriptional activator which regulates the expression of numerous rod-specific genes, such as RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001).

Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). .

Gene Information

Human
Gene Name:	NRL
Uniprot:	P54845
Entrez:	4901

Family

Belongs to:

bZIP family

Alternative Names

D14S46Eneural retina-specific leucine zipper protein; neural retina leucine zipper; NRL; NRL-MAF; RP27; RP27neural retinal-specific leucine zipper

Molecular Weight

Mass (kDA):
25.94 kDA

Genomic Context


Human

Location:	14q11.2-q12
Sequence:	14; NC_000014.9 (24078662..24114949, complement)

Tissue Specificity

Expressed in the brain and the retina (PubMed:11477108). Expressed strongly in rod and cone cells (at protein level) (PubMed:11477108).

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Latex Allergy
Allergy
Asthma
Immediate Hypersensitivity
Retinal Degeneration
Urticaria
Anaphylaxis
Retinitis Pigmentosa
Dermatitis, Allergic Contact
Retinal Diseases
Dermatitis

Spina Bifida
Blind Vision
Dermatitis, Occupational
Contact Dermatitis
Rhinorrhea
Asthma, Occupational

Interacting Proteins

OPTN

Pathways

Sensitization
Hypersensitivity
Anaphylaxis
Phototransduction
Pathogenesis
Transport
Localization
Cell Cycle
Cell Fate Determination
Type I Hypersensitivity
Cell Death
Coagulation
Innervation

Reverse Transcription
Cell Development
Cell Differentiation
Eye Development
Regeneration
Secretion
Photoreceptor Cell Development

PTMs

Phosphorylation
Acetylation
Methylation
Sumoylation

Nitration
Cleavage
Glycosylation
Oxidation

Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NRL

References

PMID: 1729696 by Swaroop A., et al. A conserved retina-specific gene encodes a basic motif/leucine zipper domain.

PMID: 9344665 by Farjo Q., et al. Human bZIP transcription factor gene NRL: structure, genomic sequence, and fine linkage mapping at 14q11.2 and negative mutation analysis in patients with retinal degeneration.