NRG3 Antibodies

AND NRG3 ELISA kits, NRG3 Proteins

Many biological assays use antibodies to detect NRG3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NRG3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NRG3 antibodies...

We validate the specificity of these antibodies to NRG3 by testing them on tissues known to express NRG3 positively and negatively. Browse below to find the NRG3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: POLQ

NRG3 Infographic by Boster Bio

All NRG3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Neuregulin-3 NRG3 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A06681
100ul

Anti-NRG3 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # M06681
100 μl/vial

NRG3 Overview

Facts about Pro-neuregulin-3, membrane-bound isoform.

NRG3 3D structure. Source: alphafold

Pro-neuregulin-3, membrane-bound isoform (NRG3)

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding leads to ligand-stimulated tyrosine phosphorylation and activation of the receptor.

Doesn't bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Gene Information

Human
Gene Name:	NRG3
Uniprot:	P56975
Entrez:	10718

Family

Belongs to:

neuregulin family

Alternative Names

HRG3; neuregulin 3 variant 1; neuregulin 3 variant 10; neuregulin 3 variant 11; neuregulin 3 variant 12; neuregulin 3 variant 13; neuregulin 3 variant 14; neuregulin 3 variant 3; neuregulin 3 variant 4; neuregulin 3 variant 5; neuregulin 3 variant 6; neuregulin 3 variant 7; neuregulin 3 variant 8; neuregulin 3 variant 9; neuregulin 3; Neuregulin3; Neuregulin-3; neuregulin-3-like polypeptide; NRG3; pro-neuregulin-3, membrane-bound isoform; pro-NRG3

Molecular Weight

Mass (kDA):
77.901 kDA

Genomic Context


Human

Location:	10q23.1
Sequence:	10; NC_000010.11 (81875190..82989979)

Tissue Specificity

Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

Subcellular Localizations

[Pro-neuregulin-3, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein. Does not seem to be active.; [Neuregulin-3]: Secreted.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Isoform 3 is also proteolytically released as a soluble form.

Diseases

Malignant Neoplasms
Schizophrenia
Malignant Neoplasm Of Breast
Neoplasms
Mammary Neoplasms
Nervousness
Carcinogenesis
Carcinoma
Delusions
Tissue Adhesions
Autistic Disorder
Malignant Neoplasm Of Liver

Multiple Myeloma
Malignant Neoplasm Of Prostate
Developmental Delay (disorder)
Malnutrition
Spinal Cord Injuries
Muscular Dystrophy, Duchenne
Hepatitis B

Pathways

Mammary Gland Development
Gland Development
Mammary Gland Morphogenesis
Gland Morphogenesis
Cell Proliferation
Pathogenesis
Cell Migration
Myelination
Cell Differentiation
Mammary Placode Formation
Erbb Signaling Pathway
Cellular Response To Dsrna
Mammary Gland Specification

Brain Development
Plasma Cell Differentiation
Platelet Aggregation
Schwann Cell Proliferation
Dsrna Fragmentation
Cognition
Hemostasis

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NRG3

References

PMID: 9275162 by Zhang D., et al. Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4.

PMID: 16478787 by Carteron C., et al. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.