NR0B2 Antibodies

Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways.

Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.

Gene Information

Human
Gene Name:	NR0B2
Uniprot:	Q15466
Entrez:	8431

Family

Belongs to:
nuclear hormone receptor family

Alternative Names

FLJ17090; NR0B2; nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2; Orphan nuclear receptor SHP; SHP; SHPSHP1; Small heterodimer partner

Molecular Weight

Mass (kDA):
28.058 kDA

Genomic Context

Human
Location:	1p36.11
Sequence:	1; NC_000001.11 (26911489..26914110, complement)

Tissue Specificity

Liver. Low levels of expression were detected in heart and pancreas.

Subcellular Localizations

Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.

Diseases

• Obesity
• Diabetes Mellitus
• Diabetes Mellitus, Non-insulin-dependent
• Insulin Resistance
• Neoplasms
• Liver Carcinoma
• Metabolic Diseases
• Carcinoma
• Malignant Neoplasms
• Liver Neoplasms
• Hepatocarcinogenesis
• Adenoma

• Congenital Absence Of Adrenal Gland
• Hypoplasia
• Cell Transformation, Neoplastic
• Male Infertility
• Cholecystolithiasis
• Congenital Hypoplasia Of Adrenal Gland
• Dyslipidemias

Interacting Proteins

• HDAC1
• HDAC3
• MDM2
• SIRT1
• TP53

Pathways

• Gluconeogenesis
• Secretion
• Transport
• Insulin Secretion
• Pathogenesis
• Gallstone Formation
• Glucose Homeostasis
• Cell Cycle
• Cell Proliferation
• Localization
• Electron Transport
• Osteoblast Differentiation
• Fatty Acid Transport

• Lipid Homeostasis
• Cell Differentiation
• Meiosis
• Induction Of Apoptosis
• Energy Homeostasis
• Demethylation
• Methylation

PTMs

• Demethylation
• Phosphorylation

• Deacetylation
• Methylation

Research Areas

• GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR0B2

Boster Bio - Best Uses Of The NR0B2 Marker

NR0B2 refers to a nuclear receptor. Researchers who employ NR0B2 in their research can earn product credits. They can also submit results for specific samples, species, and applications. All scientists around the world can benefit from the product credits. This article will provide information on the NR0B2 marker and its applications. Read on for more details. This marker can be used in many scientific applications, such as biology and the natural environment.

NR0B2

NR0B2 is a member of the nuclear receptor superfamily. This orphan member does not have the traditional DNA-binding domain however, it has a presumed binding domain. It serves as a vital transcriptional regulator in diverse metabolic processes. Its cDNA sequence, functional properties, and important biomarkers make it a valuable biomarker in a variety of research.

Nuclear receptors (NRs)

The NR0B2 marker is part of the nuclear receptor superfamily. Its heterodimer-like small coma is one of the orphan members of the NR superfamily and lacks the traditional DNA-binding domain, but conserves a putative ligand-binding domain. It plays an important part in the transcriptional regulation and the regulation of a wide range of metabolic functions. Boster Bio's NR0B2 antibody is an extremely specific and sensitive ELISA kit.

GAPDH

NR0B2 is a protein that has been fused to a GST tag at the N-terminus. This protein can be expressed in E.coli and is stable up to 12 months at temperatures below 20C. After reconstitution the protein is further diluted using assay buffer. The researcher determines the optimal concentration. It is available in oligo and lentivirus formats. The NR0B2 siRNA can be used only for research purposes. It is not designed to be used in diagnostic or therapeutic applications.

It has been shown that NR0B2 gene expression is associated with overall survival rates in various kinds of cancers. It is a great survival factor in lung, breast, and renal cancers. It has been associated with lower survival rates in the uterine corpus, thyroid, uterine, and cancers of the uterus. This gene has a divergent role in different human cancers. Further research is needed to confirm its clinical significance.

In addition to its role in the development of prostate cancer, NR0B2 is also present in many breast cancers. While it is not able to interact with other human proteins, it is known to inhibit the synthesis of several genes. Ren1 110, Ren1, Iap are just a few of these genes. For further research it is crucial to understand the mechanisms which control the production of these proteins. Below are the best applications of the NR0B2 mark.

NR0B2 can be found in the liver and certain intestinal cancers. It is a predictor in many human cancers. It could also be linked to survival of tumors as well as a biomarker for anti-PI3K response to treatment. Its upregulation could aid in the development of anti-PI3K therapy. It is important to understand how NR0B2 expression is controlled in cancerous human cells.

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The most effective use of the NR0B2 marker can be identified by determining its role in cell growth and proliferation. Its overexpression in cancer cells significantly reduced the proliferation of the renal cell carcinoma cell line, called RCC-EW. The most well-known variant of this marker is the NR0B2 mRNA. It is available from numerous vendors. The NR0B2 gene is part of the nuclear receptor subfamily zero B.