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NR0B2 Antibodies
AND NR0B2 ELISA kits, NR0B2 Proteins
Many biological assays use antibodies to detect NR0B2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR0B2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR0B2 antibodies...
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NR0B2 Infographic by Boster Bio
All NR0B2 Products
Product
Figures
Specificity
Applications
Price
Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03866-1
100 μg/vial
Cat # A03866-1
100 μg/vial
NR0B2 Overview
Facts about Nuclear receptor subfamily 0 group B member 2.
Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways.
Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.
Gene Information
| Human | |
|---|---|
| Gene Name: | NR0B2 |
| Uniprot: | Q15466 |
| Entrez: | 8431 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
FLJ17090; NR0B2; nuclear receptor subfamily 0 group B member 2; nuclear receptor subfamily 0, group B, member 2; Orphan nuclear receptor SHP; SHP; SHPSHP1; Small heterodimer partner
Molecular Weight
Mass (kDA):
28.058 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.11 |
| Sequence: | 1; NC_000001.11 (26911489..26914110, complement) |
Tissue Specificity
Liver. Low levels of expression were detected in heart and pancreas.
Subcellular Localizations
Nucleus. Cytoplasm. Colocalizes with NEUROD1 in the nucleus.
Diseases
- Obesity
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Insulin Resistance
- Neoplasms
- Liver Carcinoma
- Metabolic Diseases
- Carcinoma
- Malignant Neoplasms
- Liver Neoplasms
- Hepatocarcinogenesis
- Adenoma
Interacting Proteins
- HDAC1
- HDAC3
- MDM2
- SIRT1
- TP53
Pathways
- Gluconeogenesis
- Secretion
- Transport
- Insulin Secretion
- Pathogenesis
- Gallstone Formation
- Glucose Homeostasis
- Cell Cycle
- Cell Proliferation
- Localization
- Electron Transport
- Osteoblast Differentiation
- Fatty Acid Transport
PTMs
- Demethylation
- Phosphorylation
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR0B2
bosterbio.com/bosterbio-gene-info-cards/NR0B2
References
PMID: 8650544 by Seol W., et al. An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.
PMID: 9603951 by Lee H.-K., et al. Structure and expression of the orphan nuclear receptor SHP gene.