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Nephrin Antibodies
AND NPHS1 ELISA kits, Nephrin Proteins
Many biological assays use antibodies to detect Nephrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nephrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nephrin antibodies...
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NPHS1 Infographic by Boster Bio
All NPHS1 Products
Product
Figures
Specificity
Applications
Price
Anti-Nephrin/NPHS1 Antibody Picoband®
7 Citations 17 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # A01991
100 μg/vial
Cat # A01991
100 μg/vial
Human
ELISA
$750
Cat # EK1999
96 wells/kit, with removable strips.
Cat # EK1999
96 wells/kit, with removable strips.
NPHS1 Overview
Facts about Nephrin.
Nephrin (NPHS1)
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability.
May anchor the podocyte slit diaphragm into the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | NPHS1 |
| Uniprot: | O60500 |
| Entrez: | 4868 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
CNF; Nephrin; nephrosis 1, congenital, Finnish type (nephrin); NPHNCNF; NPHS1; Renal glomerulus-specific cell adhesion receptor
Molecular Weight
Mass (kDA):
134.742 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.12 |
| Sequence: | 19; NC_000019.10 (35825372..35851993, complement) |
Tissue Specificity
Specifically expressed in podocytes of kidney glomeruli.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Predominantly located at podocyte slit diaphragm between podocyte foot processes. Also associated with podocyte apical plasma membrane.
Diseases
- Nephrotic Syndrome
- Congenital Nephrotic Syndrome
- Proteinuria Of Undiagnosed Cause
- Kidney Diseases
- Focal Glomerulosclerosis
- Glomerulosclerosis (disorder)
- Kidney Failure, Chronic
- Steroid-resistant Nephrotic Syndrome
- Segmental Glomerulosclerosis
- Kidney Failure
- Sclerosis
- Nephrosis
- Tissue Adhesions
Interacting Proteins
- IQGAP1
- NCK1
Pathways
- Glomerular Filtration
- Pathogenesis
- Cell Adhesion
- Localization
- Glycosylation
- Excretion
- Transport
- Protein Phosphorylation
- Protein Secretion
- Oxidative Phosphorylation
- Axon Guidance
- Segmentation
- Monocyte Activation
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPHS1
bosterbio.com/bosterbio-gene-info-cards/NPHS1
References
PMID: 9660941 by Kestilae M., et al. Positionally cloned gene for a novel glomerular protein -- nephrin -- is mutated in congenital nephrotic syndrome.
PMID: 19309778 by Tikhomirov E., et al. Novel human pathological mutations. Gene symbol: NPHS1. Disease: congenital nephrotic syndrome, Finnish type.
7 Publications of Boster Nephrin Antibodies & ELISA Kits
- PubMed ID: 10.1155/2020/8263598, Protective Effects of Thalidomide on High-Glucose-Induced Podocyte Injury throug...
- PubMed ID: 31301369, Qiu Y,Zhou J,Zhang H,Zhou H,Tang H,Lei C,Ye C,You C,Chen Y,Wang Y,Xiong J,Su H,Y...
- PubMed ID: 33537831, Zhang X,Zhang L,Chen Z,Li S,Che B, Wang N,Chen J,Xu C,Wei C.Exogenous spermine a...
- PubMed ID: 32307498, Qi MY,Wang XT,Xu HL,Yang ZL,Cheng Y,Zhou B.Protective effect of ferulic acid on ...
- PubMed ID: 32908940, Liao H,Li Y,Zhang X,Zhao X,Zheng D,Shen D,Li R. Protective Effects of Thalidomid...
- PubMed ID: 26770424, Effect of simvastatin on the expression of nephrin, podocin, and vascular endoth...
- PubMed ID: 24926327, Hao L, Pan Ms, Zheng Y, Wang Rf. Exp Ther Med. 2014 Jun;7(6):1465-1470. Epub 201...
*More publications can be found for each product on its corresponding product page