Nephrocystin-3 Antibodies

AND NPHP3 ELISA kits, Nephrocystin-3 Proteins

Many biological assays use antibodies to detect Nephrocystin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nephrocystin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nephrocystin-3 antibodies...

We validate the specificity of these antibodies to Nephrocystin-3 by testing them on tissues known to express NPHP3 positively and negatively. Browse below to find the NPHP3 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPHP3 Infographic by Boster Bio

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NPHP3 Overview

Facts about Nephrocystin-3.

NPHP3 3D structure. Source: alphafold

Nephrocystin-3 (NPHP3)

Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and could also play a role in the control of non-canonical Wnt signaling which regulates planar cell polarity.

Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell moves.

Gene Information

Human
Gene Name:	NPHP3
Uniprot:	Q7Z494
Entrez:	27031

Family

Belongs to:

No superfamily

Alternative Names

FLJ30691; FLJ36696; KIAA2000DKFZp667K242; MKS7DKFZp781K1312; nephrocystin-3; nephronophthisis 3 (adolescent); NPH3MGC78666; RHPD

Molecular Weight

Mass (kDA):
150.864 kDA

Genomic Context


Human

Location:	3q22.1
Sequence:	3; NC_000003.12 (132680609..132722409, complement)

Tissue Specificity

Widely expressed at low level. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at very low level in brain and lung.

Subcellular Localizations

Cell projection, cilium. Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus.

Diseases

Nephronophthisis
Kidney Diseases
Cystic Kidney Diseases
Kidney Failure, Chronic
Kidney Failure
Retinitis Pigmentosa
Nephronophthisis 3
Fibrosis
Hydrocephalus, Normal Pressure
Nephronophthisis, Familial Juvenile
Polycystic Kidney Diseases
Nephritis, Interstitial

Situs Inversus
Dysplasia
Medullary Cystic Disease
Atrophy
Streptococcal Lymphadenitis Of Swine
Tissue Adhesions
Cystic Disease -retired-

Interacting Proteins

CEP164
UNC119

Pathways

Localization
Pathogenesis
Transport
Cell Adhesion
Gastrulation
Convergent Extension
Mitosis
Natriuresis
Anaphase
Glomerular Filtration

Pronephros Development
Translation
Pronephros Morphogenesis
Excretion

PTMs

Myristoylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPHP3

References

PMID: 12872122 by Olbrich H., et al. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis.

PMID: 12056414 by Ohara O., et al. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method.