NPC1L1 Antibodies

AND NPC1L1 ELISA kits, NPC1L1 Proteins

Many biological assays use antibodies to detect NPC1L1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPC1L1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPC1L1 antibodies...

We validate the specificity of these antibodies to NPC1L1 by testing them on tissues known to express NPC1L1 positively and negatively. Browse below to find the NPC1L1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPC1L1 Infographic by Boster Bio

All NPC1L1 Products

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Product

Figures

Specificity

Applications

Price

Anti-NPC1L1 Rabbit Monoclonal Antibody

Human

$370
Cat # M01954
100 μl/vial

NPC1L1 (NM_013389) Human Over-expression Lysate

Human

$960
Cat # LS029881
100 µg

NPC1L1 Overview

Facts about NPC1-like intracellular cholesterol transporter 1.

NPC1L1 3D structure. Source: alphafold

NPC1-like intracellular cholesterol transporter 1 (NPC1L1)

Plays a significant role in cholesterol homeostasis. Is vital for the uptake of cholesterol throughout the plasma membrane of the intestinal enterocyte.

Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption. Lack of activity leads to multiple lipid transport defects.

Gene Information

Human
Gene Name:	NPC1L1
Uniprot:	Q9UHC9
Entrez:	29881

Family

Belongs to:

patched family

Alternative Names

Niemann-Pick C1-like protein 1; NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC11L1

Molecular Weight

Mass (kDA):
148.728 kDA

Genomic Context


Human

Location:	7p13
Sequence:	7; NC_000007.14 (44512440..44541651, complement)

Tissue Specificity

Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5.