NADPH oxidase 1 Antibodies

NADPH oxidase 1 (NOX1)

NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc.

NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S doesn't contain an electron transport chain. .

Gene Information

Human
Gene Name:	NOX1
Uniprot:	Q9Y5S8
Entrez:	27035

Family

Belongs to:
No superfamily

Alternative Names

EC 1.6.3; GP91-2; Mitogenic oxidase 1; MOX-1; MOX1NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase homolog-1; NOH1; NOH1mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); NOH-1NADPH oxidase 1 variant NOH-1L; NOX1; NOX-1

Molecular Weight

Mass (kDA):
64.871 kDA

Genomic Context

Human
Location:	Xq22.1
Sequence:	X; NC_000023.11 (100843324..100874359, complement)

Tissue Specificity

NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH- 1S is detected only in colon and colon carcinoma cells.

Subcellular Localizations

Cell projection, invadopodium membrane; Multi-pass membrane protein. Cell membrane.

Diseases

• Hypertensive Disease
• Inflammation
• Malignant Neoplasms
• Atherosclerosis
• Neoplasms
• Hypertrophy
• Vascular Diseases
• Cardiovascular Diseases
• Fibrosis
• Diabetes Mellitus
• Tissue Adhesions
• Tumor Angiogenesis

• Carcinoma
• Cell Transformation, Neoplastic
• Hypoxia
• Malignant Tumor Of Colon
• Kidney Diseases
• Colonic Neoplasms

Pathways

• Cell Death
• Pathogenesis
• Cell Proliferation
• Angiogenesis
• Localization
• Cell Migration
• Cell Growth
• Rna Interference
• Transport
• Secretion
• Cell Cycle
• Cell Adhesion
• Electron Transport

• Senescence
• Inflammatory Response
• Phagocytosis
• Muscle Cell Proliferation
• Smooth Muscle Cell Proliferation
• Respiratory Burst
• Gene Silencing

PTMs

• Phosphorylation
• Oxidation
• Cleavage
• Reduction
• Dephosphorylation
• Ubiquitination
• Phosphorothioation

• Nitration
• Sumoylation
• Carboxylation
• Nitrosylation
• Glycosylation
• Deacetylation
• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NOX1

The Best Uses Of The NOX1 Marker

Boster Bio's product credits are accessible to all scientists, regardless of their experience level. Boster Bio also offers troubleshooting guides. The NOX1 marker can be used to conduct your own research to gain insight into your species or applications. Scientists from all over the world can benefit from this product credit system. Let's review some of its advantages.

Boster Bio optimization tips

Boster Bio optimization tips can be used to answer your questions about any biological process or protein. Boster Bio offers a variety of secondary antibodies, isotype-control, and detection systems that are optimized for IHC. Read on for some answers to the most frequently asked questions scientists have. This article could also help you decide whether you need a security device.

Boster Bio troubleshooting guides

Boster Bio provides comprehensive troubleshooting and protocol guides for many of its instruments in addition to standard technical assistance. These guides cover every step of the flow cytometry workflow , including sample preparation and optimization strategies. For example, a stepwise procedure for IHC offers the most appropriate methods for preparing samples and reagents. This guide provides detailed information on how to prepare and stain preserved tissues.

The NOX1 Marker has many advantages

In addition to being safe and well-tolerated, NOX1 inhibition has other benefits. It has been shown to delay the induction of pro-angiogenic and pro-inflammatory and pro-fibrotic microenvironments. Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and is the leading cause of cancer-related mortality and morbidity worldwide. HCC treatments aren't very effective and have significant side effects.

Patients with NOX1 mutations are at greater risk risk of developing inflammatory bowel disease. This is due to genetic deficiencies that affect intestinal epithelial barrier function. One study identified seven men with IBD and two had NOX1 mutations which affected the gene's function. The seven cases were examined against 16 healthy controls. Patients with the NOX1 mutations had a median age of 7.9 years. They received medical treatment using aminosalicylates or corticoids. The patient who had the mutation was also treated surgically with ileocecal stricture but there were no infections.

In addition to its beneficial effects on the immune system, NOX1 plays a vital function in antimicrobial defense. The enzyme is activated by microbial products and rapidly assembles. These molecules then generate reactive oxidant intermediates that act to defend the body against an infection. To safeguard the body from infections, neutrophils require NOX1. They include Aspergillus fumigatus Burkholderia cepacia as well as Candida albicans, all of which can cause infections in people with weakened immune systems.

Cognitive impairment is also linked to NOX activity. The activity of NOX1 decreases BDNF production, which helps in the process of stress-adaptation. Reduced BDNF levels result in depressive behaviors. Blocking the NOX1 enzyme can reduce the chance of developing depression symptoms. NOX inhibitors, once they are identified are a significant step to combat depression or anxiety.