N-myc-interactor Antibodies

N-myc-interactor (NMI)

May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription.

Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. .

Gene Information

Human
Gene Name:	NMI
Uniprot:	Q13287
Entrez:	9111

Family

Belongs to:
NMI family

Alternative Names

Nmi; N-myc (and STAT) interactor; N-myc and STAT interactor; N-myc interactor; N-myc-interactor

Molecular Weight

Mass (kDA):
35.057 kDA

Genomic Context

Human
Location:	2q23.3
Sequence:	2; NC_000002.12 (151270465..151289668, complement)

Tissue Specificity

Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Bladder Neoplasm
• Carcinoma
• Malignant Neoplasm Of Urinary Bladder
• Mental Disorders
• Carcinoma, Transitional Cell
• Pain
• Myocardial Infarction
• Infarction
• Mammary Neoplasms
• Brain Neoplasms
• Cholangiocarcinoma

• Depressive Disorder
• Ventricular Fibrillation
• Neoplasm Recurrence, Local
• Myocardial Ischemia
• Weakness
• Sclerosis
• Neoplasm Invasiveness

Interacting Proteins

• BRMS1
• C1orf216
• C9orf72
• CNKSR3
• COPS7B

• EMILIN1
• GCSH
• GOLGA8DP
• HDDC3
• HGS

• HHLA3
• LCA5L
• MAD2L1BP
• MTMR6
• MTMR9

• MYCN
• SCEL
• SFR1
• SNAPC5
• SOX10

• Sox10
• STAT5B
• TRAF5
• TUBA3E
• TXLNA

• TXLNB

Pathways

• Localization
• Translation
• Segmentation
• Transport
• Cell Proliferation
• Pathogenesis
• Angiogenesis
• Methylation
• Immune Response
• Muscle Contraction
• Cell Cycle
• Cell Death
• Locomotion

• Cell Growth
• Secretion
• Cell Migration
• Cytokinesis
• Nuclear Transport
• Cell Division
• Histone Acetylation

PTMs

• Phosphorylation
• Methylation
• Oxidation
• Formylation

• Nitration
• Cleavage
• Dephosphorylation
• Acylation

Research Areas

• Cancer
• Signal Transduction
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NMI

Boster Bio Anti-NMI Marker - The Best Uses of the NMI Marker

If you are in the market for an anti-NMI marker, you are in luck. Boster Bio has recently started offering PCR-related molecular biology products. As an added benefit, Boster Bio offers free technical resources and 24 hour support. Here are some of its best uses. Keep reading to learn more. You will be happy you did! Let's dive in! We've got the specifications and applications of this product.

Boster Bio Anti-NMI Marker

Boster Bio Anti-NMI Marker is a non-hazardous, stable antibody suitable for the detection of NMI. This anti-NMI marker has a shelf life of 24 months and does not require BSA. However, for more specific applications, it is possible to purchase blocking peptide at 1.0mg/ml. The cost of blocking peptide varies based on the length of the immunogen. Moreover, Boster Bio validates its antibodies on known positive and negative samples.

Specifications

The NMI Marker is an indicating instrument for the determination of price. Its supplementary primary indications are the number, mass, or unit price, and the total price. The designations of unit price and mass shall be horizontally aligned. The price chart should have at least one zero digit before the decimal marker. For the accuracy of the NMI Marker, the following requirements must be met:

The MPEs are defined in clauses 3.6.2.1 to 3.6.2.4. The MPEs must be at least 0.25e, or 0.50e if an auxiliary indicating device is used. The load receptors should be stable under rolling loads and minimal off-centre loading. Some NMI Marker models are capable of combining multiple loads. You must make sure that your instrument meets all the MPE requirements before purchasing.

Applications

The invention belongs to the technical field of poultry molecular marker preparation and relates to cloning of the NMI gene fragment and assisted selection of characters influencing chicken embryo death. The world's largest chicken producer, China has been ranked first in egg production for years. Currently, China's egg output ranks second only to the U.S. Egg production affects the production efficiency and economic benefit of raising chickens.

The hNMI protein from insect cells is known to stimulate TNF release by THP1 cells, a human monocytic cell line. This indicates that the NMI protein is a potential therapeutic target in clinical intervention. In addition, the hNMI protein stimulates the inflammatory response of macrophages. Therefore, a clinical trial focusing on this protein is warranted. Although this study is in its initial stages, it may provide useful insight into the physiology of various cardiac disorders.

Chromobodies(r) are intracellular functional antibodies that allow scientists to monitor dynamic changes in target proteins in live cells. The Chromobody (r) will be introduced into difficult-to-transfect cell lines. Moreover, pharmaceutical companies will benefit from the lentiviral transduction of their own cell lines, which will enhance HCA capabilities. Chromobody(r) nanoprobes will lift the preclinical compound screening and pathway analysis.

The NMI marker stimulates immune responses through the TLR4 pathway. It is not associated with cell surface TLRs TLR2, TLR1, and TLR635 as other TLRs do. The TLR4 and NMI are endosomal receptors and thus, do not co-bind with these proteins. This is the basis for the development of therapies targeting the NMI Marker. There are several other applications of the NMI marker.

The NMI Marker was also evaluated for the potential to induce ventricular fibrillation in humans. The NMI Marker was proven to induce ventricular fibrillation in humans by using a standard Taser X-26 discharge. The researchers derived these results by building a custom NMI marker device that produced electrical discharges with waveform characteristics similar to those of the Taser. The experimental device allowed them to vary the output capacitance and sensitivity as needed.