NME8 Antibodies

AND NME8 ELISA kits, NME8 Proteins

Many biological assays use antibodies to detect NME8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NME8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NME8 antibodies...

We validate the specificity of these antibodies to NME8 by testing them on tissues known to express NME8 positively and negatively. Browse below to find the NME8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NME8 Infographic by Boster Bio

All NME8 Products

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Specificity

Applications

Price

TXNDC3 (NME8) (NM_016616) Human Over-expression Lysate

Human

$628
Cat # LS051314
100 µg

Anti-TXNDC3/NME8 Antibody Picoband®

Human, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A08723-1
100 μg/vial

NME8 Overview

Facts about Thioredoxin domain-containing protein 3.

NME8 3D structure. Source: alphafold

Thioredoxin domain-containing protein 3 (NME8)

Likely required during the final stages of sperm tail maturation from the testis or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins happens. May be involved in the reduction of disulfide bonds within the semen FS components.

In vitro, it's neither NDP kinase nor reducing activity on disulfide bonds. .

Gene Information

Human
Gene Name:	NME8
Uniprot:	Q8N427
Entrez:	51314

Family

Belongs to:

No superfamily

Alternative Names

CILD6Sptrx-2; EC 2.1.1.31; EC 2.5.1.6; NM23-H8; NME8thioredoxin domain-containing protein 3; Spermatid-specific thioredoxin-2; sperm-specific thioredoxin 2; SPTRX2sptrx-2; thioredoxin domain containing 3 (spermatozoa)

Molecular Weight

Mass (kDA):
67.27 kDA

Genomic Context


Human

Location:	7p14.1
Sequence:	7; NC_000007.14 (37848597..37900397)

Tissue Specificity

Testis-specific. Expressed only in primary spermatocytes and round spermatids.

Subcellular Localizations

Cytoplasm.

Diseases

Degenerative Polyarthritis
Male Infertility
Infertility
Ciliary Motility Disorders
Dyskinetic Syndrome
Neoplasms
Infective Disorder
Neoplasm Metastasis
Hereditary Diseases

Allelic Imbalance
Kartagener Syndrome
Osteoarthritis, Knee
Respiratory Tract Infections

Pathways

Aging
Pachytene
Pathogenesis

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NME8

References

PMID: 11768308 by Lacombe M.-L.L., et al. The human Nm23/nucleoside diphosphate kinases.

PMID: 11737268 by Sadek C.M., et al. Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.