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- Table of Contents
1 Citations 1 Q&As
1 Citations 5 Q&As
Facts about Nucleoside diphosphate kinase A.
Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Human | |
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Gene Name: | NME1 |
Uniprot: | P15531 |
Entrez: | 4830 |
Belongs to: |
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NDK family |
EC 2.7.4.6; GAAD; Granzyme A-activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDKA; NDP kinase A; NDPKA; NDPK-A; NM23A; NM23AWD; NM23H1; NM23-H1; NME1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; Tumor metastatic process-associated protein
Mass (kDA):
17.149 kDA
Human | |
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Location: | 17q21.33 |
Sequence: | 17; NC_000017.11 (51153559..51162168) |
Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.
Cytoplasm. Nucleus. Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.
There are a variety of ways to determine NME1 proteins in cells. One method is immunohistochemistry, which makes use of antibody-antigen interactions to visualize the distribution and localization of specific cellular components. Researchers have optimized the staining and preparation methods to create strong signals. These results can be interpreted in many ways. But, one mistake to avoid is mixing NME1 and other markers within the same stain.
NME1 is an epigenetic marker of the sphere cell that has enhanced capacity to grow. This marker can cause sphere cells to grow as primary tumors and to colonize lung tissues. The most effective uses of NME1 are being studied at present. Further study of this marker will require creation of new approaches to research. The NME1 gene could be a valuable tool for researchers. However, more research into its role in tumor growth is needed.
A high-quality and reliable Histology kit from Boster Bio ELISA is essential if you are looking to get a consistent and accurate result. Boster Bio's proprietary coatings and blocking techniques ensure consistent results, and minimize the chance of error in tests. They are tested against biologically relevant matrices like blood plasma and cell culture supernatants. All ELISA kits are subject to strict lot-to-lot stability testing. The validation images are available on the Boster Bio website.
Boster Bio is an antibody manufacturer that focuses on high-affinity and specificity antibodies with high-specificity. The Boster Bio product line includes more than 12,000 antibodies, that have been validated for various applications like IHC, WB, Flow Cytometry, and ELISA. Boster Bio antibodies have been rigorously tested against over 250 tissue panels, which results in high specificity and high affinity. Boster Bio also offers a variety of immunological products.
Suo You Boster Ti He is a great choice for those who are just beginning their journey in the field. Boster Kang Ti in Chinese means "wonderful swinging wings".
Boster Bio is a company that produces antibodies for various types of cells. Its products include immunohistochemistry kit, Western blotting and ELISAs. The three products are all made up of immunoreactive proteins. These products allow researchers to visualize the distribution and the location of cells' components. PicoKine(tm) their exclusive ELISA platform, makes use of trade secrets to provide high-sensitivity ELISA kit kits.
PMID: 2509941 by Rosengard A.M., et al. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development.
PMID: 1851158 by Gilles A.-M., et al. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme.
*More publications can be found for each product on its corresponding product page