NME1 Antibodies

Nucleoside diphosphate kinase A (NME1)

The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities.

Involved in cell proliferation, differentiation and development, signal transduction, G protein- coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.

Gene Information

Human
Gene Name:	NME1
Uniprot:	P15531
Entrez:	4830

Family

Belongs to:
NDK family

Alternative Names

EC 2.7.4.6; GAAD; Granzyme A-activated DNase; Metastasis inhibition factor nm23; NB; NBS; NDK A; NDKA; NDP kinase A; NDPKA; NDPK-A; NM23A; NM23AWD; NM23H1; NM23-H1; NME1; non-metastatic cells 1, protein (NM23A) expressed in; nucleoside diphosphate kinase A; Tumor metastatic process-associated protein

Molecular Weight

Mass (kDA):
17.149 kDA

Genomic Context

Human
Location:	17q21.33
Sequence:	17; NC_000017.11 (51153559..51162168)

Tissue Specificity

Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression is also related to tumor differentiation.

Subcellular Localizations

Cytoplasm. Nucleus. Cell-cycle dependent nuclear localization which can be induced by interaction with Epstein-barr viral proteins or by degradation of the SET complex by GzmA.

Diseases

• Neoplasms
• Neoplasm Metastasis
• Malignant Neoplasms
• Carcinoma
• Cell Invasion
• Malignant Neoplasm Of Breast
• Lymphatic Metastasis
• Mammary Neoplasms
• Malignant Paraganglionic Neoplasm
• Metastatic Malignant Neoplasm To The Lymph Node
• Adenocarcinoma
• Neoplasm Invasiveness
• Malignant Squamous Cell Neoplasm

• Melanoma
• Lung Neoplasms
• Colorectal Cancer
• Tumor Progression
• Liver Neoplasms
• Colorectal Neoplasms
• Malignant Neoplasm Of Lung

Interacting Proteins

• Ksr1
• MCF2
• NME2
• NME3
• NME4

• PID1
• POLR1C
• PRUNE1
• SREK1IP1
• STRAP

• TNPO2
• WDYHV1

Pathways

• Cell Proliferation
• Cell Migration
• Localization
• Cell Growth
• Cell Cycle
• Cell Motility
• Cell Adhesion
• Angiogenesis
• Reverse Transcription
• Cell Differentiation
• Pathogenesis
• Translation

• Cell Death
• Dna Repair
• S Phase
• Secretion
• Interphase
• Endocytosis
• Oncogenesis

PTMs

• Phosphorylation
• Cleavage
• Methylation

• Sumoylation
• Deacetylation
• Glycosylation

• Amidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NME1

Best Uses Of The NME1 Marker

There are a variety of ways to determine NME1 proteins in cells. One method is immunohistochemistry, which makes use of antibody-antigen interactions to visualize the distribution and localization of specific cellular components. Researchers have optimized the staining and preparation methods to create strong signals. These results can be interpreted in many ways. But, one mistake to avoid is mixing NME1 and other markers within the same stain.

Steven Boster

NME1 is an epigenetic marker of the sphere cell that has enhanced capacity to grow. This marker can cause sphere cells to grow as primary tumors and to colonize lung tissues. The most effective uses of NME1 are being studied at present. Further study of this marker will require creation of new approaches to research. The NME1 gene could be a valuable tool for researchers. However, more research into its role in tumor growth is needed.

Histology

A high-quality and reliable Histology kit from Boster Bio ELISA is essential if you are looking to get a consistent and accurate result. Boster Bio's proprietary coatings and blocking techniques ensure consistent results, and minimize the chance of error in tests. They are tested against biologically relevant matrices like blood plasma and cell culture supernatants. All ELISA kits are subject to strict lot-to-lot stability testing. The validation images are available on the Boster Bio website.

Boster Bio is an antibody manufacturer that focuses on high-affinity and specificity antibodies with high-specificity. The Boster Bio product line includes more than 12,000 antibodies, that have been validated for various applications like IHC, WB, Flow Cytometry, and ELISA. Boster Bio antibodies have been rigorously tested against over 250 tissue panels, which results in high specificity and high affinity. Boster Bio also offers a variety of immunological products.

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Immunohistochemistry

Boster Bio is a company that produces antibodies for various types of cells. Its products include immunohistochemistry kit, Western blotting and ELISAs. The three products are all made up of immunoreactive proteins. These products allow researchers to visualize the distribution and the location of cells' components. PicoKine(tm) their exclusive ELISA platform, makes use of trade secrets to provide high-sensitivity ELISA kit kits.