NLRP1 Antibodies

AND NLRP1 ELISA kits, NLRP1 Proteins

Many biological assays use antibodies to detect NLRP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLRP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLRP1 antibodies...

We validate the specificity of these antibodies to NLRP1 by testing them on tissues known to express NLRP1 positively and negatively. Browse below to find the NLRP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NLRP1 Infographic by Boster Bio

All NLRP1 Products

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Anti-NALP1 NLRP1 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A00777
0.1 mg

NALP1 (NLRP1) (NM_033004) Human Over-expression Lysate

Human

$960
Cat # LS022861
100 µg

NLRP1 Overview

Facts about NACHT, LRR and PYD domains-containing protein 1.

NLRP1 3D structure. Source: alphafold

NACHT, LRR and PYD domains-containing protein 1 (NLRP1)

As the sensor part of this NLRP1 inflammasome, plays an essential role in innate immunity and inflammation. In response to pathogens and other damage-associated signs, initiates the creation of the inflammasome polymeric complex, made from NLRP1, CASP1, and possibly PYCARD.

Activation of NLRP1 inflammasome is also needed for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses.

Gene Information

Human
Gene Name:	NLRP1
Uniprot:	Q9C000
Entrez:	22861

Family

Belongs to:

NLRP family

Alternative Names

CARD7; CARD7SLEV1; Caspase recruitment domain-containing protein 7; CLR17.1; Death effector filament-forming ced-4-like apoptosis protein; DEFCAP; DEFCAPVAMAS1; DKFZp586O1822; KIAA0926DEFCAP-L/S; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACPP1044; NALP1; NALP1caspase recruitment domain protein 7; NLR family, pyrin domain containing 1; NLRP1; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization d

Molecular Weight

Mass (kDA):
165.866 kDA

Genomic Context


Human

Location:	17p13.2
Sequence:	17; NC_000017.11 (5501396..5584509, complement)

Tissue Specificity

Widely expressed (PubMed:11113115, PubMed:17164409). Abundantly expressed in primary immune cells (isoform 1 and isoform 2), including in neutrophils, monocytes/macrophages, dendritic cells (mostly Langerhans cells), and B- and T-lymphocytes (at protein level) (PubMed:15285719, PubMed:17164409). Strongly expressed in epithelial cells lining the glandular epithelium, such as that of the gastrointestinal tract (stomach, small intestine, colon), the respiratory tract (trachea and bronchi), and the endometrial and endocervical glands, gallbladder, prostate, and breast (at protein level). In testis, expressed in spermatogonia and primary spermatocytes, but not in Sertoli cells (at protein level). In the brain, expressed in neurons, in particular in pyramidal ones and in oligodendrocytes, but not detected in microglia (at protein level) (PubMed:17164409). Expressed in adult and fetal ocular tissues, including in adult and 24-week old fetal choroid, sclera, cornea, and optic nerve, as well as in adult retina and fetal retina/retinal pigment epithelium (PubMed:23349227). Highly expressed in the skin throughout the epidermis and in dermal fibroblasts, in both glabrous skin and plantar skin.

Subcellular Localizations

Cytoplasm, cytosol. Cytoplasm. Inflammasome. Nucleus. Nucleocytoplasmic distribution in lymphoid organs (probably in T-cells) and in neurons. In epithelial cells, predominantly cytoplasmic.