Nlk Antibodies

AND Nlk ELISA kits, Nlk Proteins

Many biological assays use antibodies to detect Nlk, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nlk in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nlk antibodies...

We validate the specificity of these antibodies to Nlk by testing them on tissues known to express Nlk positively and negatively. Browse below to find the Nlk antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nlk Infographic by Boster Bio

All Nlk Products

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Product

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Specificity

Applications

Price

Anti-NLK Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A02091
100ul

Anti-NLK Antibody

Human

$299
Cat # M02091
80 µl

Anti-NLK Rabbit Monoclonal Antibody

Human

Flow Cytometry, WB

$370
Cat # M02091-1
100 μl/vial

NLK (NM_016231) Human Over-expression Lysate

Human

$628
Cat # LS051701
100 µg

Nlk Overview

Facts about Serine/threonine-protein kinase NLK.

Serine/threonine-protein kinase NLK (Nlk)

Serine/threonine-protein kinase that modulates a variety of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2.

Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK- SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters in histone H3K9 and transcriptional silencing.

Gene Information

Mouse
Gene Name:	Nlk
Uniprot:	O54949
Entrez:	18099

Family

Belongs to:

protein kinase superfamily

Alternative Names

DKFZp761G1211; EC 2.7.11; EC 2.7.11.24; FLJ21033; LAK1; nemo like kinase; nemo-like kinaseserine/threonine-protein kinase NLK; Protein LAK1

Molecular Weight

Mass (kDA):
58.313 kDA

Genomic Context


Mouse

Location:	11\|11 B5
Sequence:	11;

Tissue Specificity

Expressed at high levels in the brain, and at lower levels in heart, kidney, lung and liver.

Diseases

Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Carcinoma
Carcinogenesis
Cell Invasion
Tissue Adhesions
Malignant Neoplasm Of Stomach
Malignant Paraganglionic Neoplasm
Malignant Neoplasm Of Liver
Malignant Tumor Of Colon
Cell Transformation, Neoplastic
Liver Carcinoma

Malignant Neoplasm Of Pancreas
Stomach Neoplasms
Liver Neoplasms
Ovarian Neoplasm
Malignant Neoplasm Of Ovary
Colorectal Cancer
Neoplasm Invasiveness

Pathways

Cell Motility
Cell Growth
Secretion
Cell Proliferation
Localization
Cell Adhesion
Pathogenesis
Glycolysis
Methylation
Cell Death
Rna Interference
Regeneration
Histone H3-k9 Methylation

Translation
Cell Cycle
Mesoderm Formation
Cell Differentiation
Eye Development
Glycosylation
Hatching

PTMs

Phosphorylation
Ubiquitination
Cleavage

Methylation
Glycosylation
Acetylation

Dephosphorylation

Research Areas

Protein Kinase
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nlk

References

PMID: 9448268 by Brott B.K., et al. Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus.

PMID: 10391247 by Ishitani T., et al. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF.