NFKBIA Antibodies

AND NFKBIA ELISA kits, NFKBIA Proteins

Many biological assays use antibodies to detect NFKBIA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFKBIA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFKBIA antibodies...

We validate the specificity of these antibodies to NFKBIA by testing them on tissues known to express NFKBIA positively and negatively. Browse below to find the NFKBIA antibody that suites your experiment. We have 16 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NFKBIA Infographic by Boster Bio

All NFKBIA Products

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Product

Figures

Specificity

Applications

Price

Anti-IKB alpha/NFKBIA Antibody Picoband®

13 Citations 1 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PB9291
100 μg/vial

Anti-Phospho-IKB alpha (S32) NFKBIA Rabbit Monoclonal Antibody

2 Citations 1 Q&As

Human

IP, WB

$370
Cat # P01139
100 μl

Anti-IKB alpha NFKBIA Rabbit Monoclonal Antibody

3 Citations

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M01139
100 μl

Anti-IkB-a (Ab-32/36) NFKBIA Antibody

2 Citations

Human, Mouse

IF, IHC, WB

$360
Cat # A01139-1
100 µl

IkappaB-alpha Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1311
1 kit, containing one 96-well plate and all necessary reagents

IkappaB-alpha (Phospho-Tyr305) Colorimetric Cell-Based ELISA Kit

3 Q&As

Human, Mouse, Rat

ELISA

$540
Cat # EKC2295
1 kit, containing two 96-well plates and all necessary reagents

IkappaB-alpha (Phospho-Ser32/Ser36) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2439
1 kit, containing two 96-well plates and all necessary reagents

Anti-IkB-Alpha (phospho-S32/S36) NFKBIA Antibody

Human, Mouse, Rat

IF, IHC, WB

$482
Cat # A01139S32S36
100ul

Anti-IkB-Alpha (phospho-Y42) NFKBIA Antibody

Human, Mouse, Rat

IHC, WB

$482
Cat # A01139Y42
100ul

Anti-IKB Alpha NFKBIA Antibody

1 Citations

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$405
Cat # A01139
100ul

Anti-IKB Alpha (Phospho-S32) NFKBIA Antibody

Human

ICC, WB

$405
Cat # A01139S32
100ul

Anti-Phospho-kappa-alpha (Y305) NFKBIA Antibody

Human, Monkey, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A01139Y305
100ul

Human IkB-alpha Recombinant Protein

SDS-PAGE

$265
Cat # PROTP25963
Starting from 10ug

Anti-Phospho-IKB alpha (S36) Rabbit Monoclonal Antibody

6 Citations

Human, Mouse

Flow Cytometry, WB

$370
Cat # P01139-1
100 μl/vial

IKB alpha (NFKBIA) (NM_020529) Human Over-expression Lysate

Human

$628
Cat # LS004792
100 µg

Anti-Phospho-IKB alpha (Y42) Rabbit Monoclonal Antibody

Human

$370
Cat # M01139Y42
100 µl/vial

NFKBIA Overview

Facts about NF-kappa-B inhibitor alpha.

NFKBIA 3D structure. Source: alphafold

NF-kappa-B inhibitor alpha (NFKBIA)

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers from the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by resistant and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate into the nucleus and activate transcription.

Gene Information

Human
Gene Name:	NFKBIA
Uniprot:	P25963
Entrez:	4792

Family

Belongs to:

NF-kappa-B inhibitor family

Alternative Names

alpha; I-kappa-B-alpha; IkappaBalphaNF-kappa-B inhibitor alpha; IKBAikB-alpha; IkBalpha; IkB-alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor

Molecular Weight

Mass (kDA):
35.609 kDA

Genomic Context


Human

Location:	14q13.2
Sequence:	14; NC_000014.9 (35401513..35404749, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

Diseases

Neoplasms
Malignant Neoplasms
Inflammation
Inflammatory Response
Lymphoma
Malignant Paraganglionic Neoplasm
Hodgkin Disease
Carcinoma
Tissue Adhesions
Innate Immune Response
Neoplasm Metastasis
Autoimmune Diseases
Crohn Disease

Autoimmune Reaction
Glioblastoma
Dysequilibrium Syndrome
Infective Disorder
Malignant Neoplasm Of Breast
Cell Transformation, Neoplastic
Cholangiocarcinoma

Interacting Proteins

CHUK
COMMD1
CTNNA1
FBXW11
GRK2

GRK5
HIF1AN
IKBKB
IKBKG
NEDD9

NFKB1
NFKB2
REL
RELA
RPS3

Pathways

Immune Response
Inflammatory Response
Pathogenesis
Cell Proliferation
Translation
Innate Immune Response
Cell Death
Cell Cycle
Cytokine Production
Localization
Methylation
Rna Interference
Secretion

Response To Lipopolysaccharide
Cell Adhesion
Cell Migration
Programmed Cell Death
Gene Silencing
Aging
Regulation Of Gene Expression

PTMs

Phosphorylation
Biotinylation

Acetylation
Methylation

Research Areas

Apoptosis
Chaperone-Mediated Autophagy (CMA)
Diabetes Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFKBIA

References

PMID: 1829648 by Haskill S., et al. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.

PMID: 10637284 by Jungnickel B., et al. Clonal deleterious mutations in the IkappaB alpha gene in the malignant cells in Hodgkin's lymphoma.

21 Publications of Boster NFKBIA Antibodies & ELISA Kits

PubMed ID: 10.4314/tjpr.v16i11.13, Prophylactic effects of triptolide on colon cancer development in azoxymethane/d...
PubMed ID: 10.3389/fphys.2021.707344, Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-...
PubMed ID: 10.3109/13880209.2014.898075, Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-κB activation and C...
PubMed ID: 10.1620/tjem.222.7, Growth Hormone Releasing Peptide-2, a Ghrelin Agonist, Attenuates Lipopolysaccha...
PubMed ID: 10.1111/j.1745-7270.2006.00136.x, Regulatory Peptides Modulate Adhesion of Polymorphonuclear Leukocytes to Bronchi...
PubMed ID: 10.1111/[email protected], Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the m...
PubMed ID: 10.1111/febs.13767, Low doses of paclitaxel enhance liver metastasis of breast cancer cells in the m...
PubMed ID: 10.1016/j.jtemb.2011.04.001, The effect of DHEA treatment on the oxidative stress and myocardial fibrosis ind...
PubMed ID: 10.1016/j.jff.2015.08.032, Ameliorative effectiveness of allicin on acetaminophen-induced acute liver damag...
PubMed ID: 10.1016/j.intimp.2021.108119, Nootkatone protects cartilage against degeneration in mice by inhibiting NF-κB ...
PubMed ID: 10.1016/j.clim.2021.108914, Epigenetic regulation is involved in traffic-related PM2.5 aggravating allergic ...
PubMed ID: 10.1007/s10753-010-9197-0, Norisoboldine Inhibits the Production of Pro-inflammatory Cytokines in Lipopolys...
PubMed ID: 10.1007/s00253-021-11719-8, Surfactin-oleogel with therapeutic potential for inflammatory acne vulgaris indu...
PubMed ID: -, Huanyue Cui,Xueying Liu,Jin Zhang,Ke Zhang,Dahong Yao,Shi Dong,Shushu Feng,Lu Ya...
PubMed ID: 24889421, N-acetylcysteine reduces oxidative stress, nuclear factor-?B activity and cardio...
PubMed ID: 26046540, Downregulation of TNIP1 Expression Leads to Increased Proliferation of Human Ker...
PubMed ID: 20208988, Multi-gene targeted antiangiogenic therapies for experimental corneal neovascula...
PubMed ID: 27350130, Rumen-derived lipopolysaccharide enhances the expression of lingual antimicrobia...
PubMed ID: 28694207, Liao, Z., Wang, J., Tan, H., & Wei, L. (2017). Cinnamon extracts exert intrapanc...
PubMed ID: 20193848, Liu X, Yu H, Yang W, Zhou X, Lu H, Shi D. Cancer Genet Cytogenet. 2010 Mar;197(2...
PubMed ID: 25820389, Xu T, Ni Mm, Huang C, Meng Xm, He Yh, Zhang L, Li J. Inflammation. 2015 Oct;38(5...

*Showing only the more recent 20. More publications can be found for each product on its corresponding product page