NFE2L2 Antibodies

AND NFE2L2 ELISA kits, NFE2L2 Proteins

Many biological assays use antibodies to detect NFE2L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NFE2L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NFE2L2 antibodies...

We validate the specificity of these antibodies to NFE2L2 by testing them on tissues known to express NFE2L2 positively and negatively. Browse below to find the NFE2L2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NFE2L2 Infographic by Boster Bio

All NFE2L2 Products

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Specificity

Applications

Price

Anti-Phospho-Nrf2 (S40) NFE2L2 Rabbit Monoclonal Antibody

5 Citations 3 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # P00078
100 μl

Anti-Nrf2 NFE2L2 Rabbit Monoclonal Antibody

9 Citations 3 Q&As

Human, Mouse

IP, IF, IHC, ICC, WB

$370
Cat # M00078
100 μl

NFE2L2 Nuclear Factor Erythroid 2-Like 2 Human Recombinant Protein

Human

$250
Cat # PROTQ16236
2ug, 10ug, 100ug

Nrf2 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1408
1 kit, containing one 96-well plate and all necessary reagents

Anti-NFE2L2 Antibody Picoband®

9 Citations

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00078-1
100 μg/vial

Anti-NRF2/NFE2L2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00078-2
100 μg/vial

NFE2L2 Overview

Facts about Nuclear factor erythroid 2-related factor 2.

NFE2L2 3D structure. Source: alphafold

Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress and the regulation of cellular redox conditions.

May be involved in the transcriptional activation of genes of this beta-globin audience by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. .

Gene Information

Human
Gene Name:	NFE2L2
Uniprot:	Q16236
Entrez:	4780

Family

Belongs to:

bZIP family

Alternative Names

HEBP1; NFE2L2; NF-E2-related factor 2; NFE2-related factor 2; NRF2 erythroid derived 2, like 2; Nrf2 ihc; Nrf2 immunofluorescence; Nrf2 immunohistochemistry; Nrf2 polyclonal; Nrf2 rat; Nrf2 western blot; Nrf2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2

Molecular Weight

Mass (kDA):
67.827 kDA

Genomic Context


Human

Location:	2q31.2
Sequence:	2; NC_000002.12 (177230303..177265131, complement)

Tissue Specificity

Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.

Subcellular Localizations

Cytoplasm, cytosol. Nucleus. Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497).

Diseases

Malignant Neoplasms
Inflammation
Neoplasms
Carcinogenesis
Carcinoma
Neurodegenerative Disorders
Liver Carcinoma
Cell Transformation, Neoplastic
Parkinson Disease
Lung Diseases
Lung Neoplasms
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung

Injury To Liver
Diabetes Mellitus
Adenocarcinoma
Inflammatory Response
Nerve Degeneration
Mammary Neoplasms
Chronic Obstructive Airway Disease

Interacting Proteins

ATF4
KEAP1
MAFG
MAFK
Pml

RARA
Rara
TNNT1
WAC

Pathways

Cell Death
Pathogenesis
Localization
Response To Oxidative Stress
Neuroprotection
Aging
Cell Proliferation
Inflammatory Response
Cell Growth
Cell Cycle
Secretion
Conjugation
Transport

Angiogenesis
Rna Interference
Autophagy
Excretion
Translation
Drug Resistance
Nuclear Export

PTMs

Phosphorylation
Ubiquitination
Oxidation
Cleavage
Reduction
Acetylation
Methylation

Nitrosylation
Deacetylation
Sumoylation
Demethylation
Carboxylation
Glutathionylation
Nitration

Biotinylation

Research Areas

Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NFE2L2

References

PMID: 7937919 by Moi P., et al. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF- E2/AP1 repeat of the beta-globin locus control region.

PMID: 11035812 by Huang H.-C., et al. Regulation of the antioxidant response element by protein kinase C- mediated phosphorylation of NF-E2-related factor 2.

18 Publications of Boster NFE2L2 Antibodies & ELISA Kits

PubMed ID: 10.3390/molecules23071788, Protection of Anthocyanin from Myrica rubra against Cerebral Ischemia-Reperfusio...
PubMed ID: 10.3389/fnagi.2020.00226, Lactulose and Melibiose Attenuate MPTP-Induced Parkinson’s Disease in Mice by ...
PubMed ID: 10.1186/s13578-021-00734-x, Maresin conjugates in tissue regeneration-1 suppresses ferroptosis in septic acu...
PubMed ID: 10.1111/jphp.13343, Modulation of non‐steroidal anti‐inflammatory drug‐induced, ER stress‐me...
PubMed ID: 10.1039/C6RA14831J, Individual and combined antioxidant effects of ginsenoside F2 and cyanidin-3-O-g...
PubMed ID: 10.1016/j.toxlet.2017.07.215, MicroRNA-155 regulates arsenite-induced malignant transformation by targeting Nr...
PubMed ID: 10.1016/j.bbrc.2017.08.089, Procyanidin B2 ameliorates carrageenan-induced chronic nonbacterial prostatitis ...
PubMed ID: 10.1007/s12013-019-00890-5, Grape Seed Procyanidins Attenuates Cisplatin-induced Human Embryonic Renal Cell ...
PubMed ID: 10.1002/tox.22374, Protection of Nrf2 against arsenite‐induced oxidative damage is regulated by t...
PubMed ID: 31026730, Xin X,Yao D,Zhang K,Han S,Liu D,Wang H,Liu X,Li G,Huang J,Wang J.Protective effe...
PubMed ID: 34116043, Chen M,Wang Z,Zhou W,Lu C,Ji T,Yang W,Jin Z,Tian Y,Lei W,Wu S,Fu Q,Wu Z,Wu X,Han...
PubMed ID: -, Huanyue Cui,Xueying Liu,Jin Zhang,Ke Zhang,Dahong Yao,Shi Dong,Shushu Feng,Lu Ya...
PubMed ID: 33359640, Li D,Bai X,Jiang Y,Cheng Y.Butyrate alleviates PTZ-induced mitochondrial dysfunc...
PubMed ID: 32030632, Li X,Zuo C,Sun D,Zhao T,Zhang Z.Arsenite Increases Linc-ROR in Human Bronchial E...
PubMed ID: 27529235, Protective effects of berberine on renal injury in streptozotocin (STZ)-induced ...
PubMed ID: 28939896, miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing ...
PubMed ID: 27774770, Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the...
PubMed ID: 27484042, The protective role of vitamin D3 in a murine model of asthma via the suppressio...

*More publications can be found for each product on its corresponding product page