Nfatc2ip Antibodies

AND Nfatc2ip ELISA kits, Nfatc2ip Proteins

Many biological assays use antibodies to detect Nfatc2ip, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nfatc2ip in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nfatc2ip antibodies...

We validate the specificity of these antibodies to Nfatc2ip by testing them on tissues known to express Nfatc2ip positively and negatively. Browse below to find the Nfatc2ip antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nfatc2ip Infographic by Boster Bio

All Nfatc2ip Products

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Product

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Specificity

Applications

Price

Anti-NFATC2-interacting protein NFATc2IP Antibody

Human

ELISA, WB

$380
Cat # A11329
100ul

NFATC2IP (NM_032815) Human Over-expression Lysate

Human

$628
Cat # LS084901
100 µg

Nfatc2ip Overview

Facts about NFATC2-interacting protein.

NFATC2-interacting protein (Nfatc2ip)

In T-helper 2 (Th2) cells, regulates the size of NFAT-driven transcription of a particular subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 into the IL4 promoter; this leads to enhancement of histone H4'Arg-3'- methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression.

Down- regulates formation of poly-SUMO chains by UBE2I/UBC9. .

Gene Information

Mouse
Gene Name:	Nfatc2ip
Uniprot:	O09130
Entrez:	18020

Family

Belongs to:

No superfamily

Alternative Names

45 kDa NF-AT-interacting protein; ESC2; FLJ14639; MGC126790; MGC138387; NFATC2-interacting protein; NIP4545 kDa NFAT-interacting protein; Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2interacting protein; RAD60

Molecular Weight

Mass (kDA):
45.121 kDA

Genomic Context


Mouse

Location:	7 F3\|7 69.01 cM
Sequence:	7;

Tissue Specificity

Highest level detected in spleen, thymus and testis.

Diseases

Pneumonia
Infective Disorder
Immunologic Deficiency Syndromes
Common Variable Immunodeficiency
Hypogammaglobulinemia
Rheumatic Heart Disease
Trichinellosis
Inflammation

Lymphoma
Bacterial Infections

Pathways

Methylation
Immune Response
Osteoclast Differentiation
Cytokine Production
Cell Death
Protein Targeting
Cell Differentiation
Dna Repair
Localization

Bone Resorption
Conjugation
Secretion

PTMs

Methylation

Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nfatc2ip

References

PMID: 8943202 by Hodge M.R., et al. NF-AT-driven interleukin-4 transcription potentiated by NIP45.

PMID: 11435475 by Lieberson R., et al. Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT- interacting protein (NIP45).