Sialidase-1 Antibodies

AND NEU1 ELISA kits, Sialidase-1 Proteins

Many biological assays use antibodies to detect Sialidase-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sialidase-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sialidase-1 antibodies...

We validate the specificity of these antibodies to Sialidase-1 by testing them on tissues known to express NEU1 positively and negatively. Browse below to find the NEU1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NEU1 Infographic by Boster Bio

All NEU1 Products

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Human NEU-1/Sialidase-1 Recombinant Protein

2 Q&As

SDS-PAGE

$265
Cat # PROTQ99519
Starting from 20ug

Anti-Neuraminidase (NEU1) Mouse Monoclonal Antibody [Clone ID: OTI3D4]

Human

IHC, WB

$523
Cat # M02270
100 µl

NEU1 Overview

Facts about Sialidase-1.

NEU1 3D structure. Source: alphafold

Sialidase-1 (NEU1)

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it's strictly dependent on its existence in the multienzyme complex.

Appears to have a taste for alpha 2-3 and alpha 2-6 sialyl linkage. .

Gene Information

Human
Gene Name:	NEU1
Uniprot:	Q99519
Entrez:	4758

Family

Belongs to:

glycosyl hydrolase 33 family

Alternative Names

Acetylneuraminyl hydrolase; EC 3.2.1.18; exo-alpha-sialidase; FLJ93471; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; NANH; NEU; NEU1; NEU-1; SIAL1; sialidase 1 (lysosomal sialidase); Sialidase-1

Molecular Weight

Mass (kDA):
45.467 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31857659..31862821, complement)

Tissue Specificity

Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain.

Subcellular Localizations

Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle. Lysosome. Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles.

Diseases

Type I Mucolipidosis
Mucolipidoses
Lysosomal Storage Diseases
Galactosialidosis
Neuraminidase 1 Deficiency
Tissue Adhesions
Storage Disease
Neoplasms
Edema
Hydrops Fetalis
Malignant Neoplasms
Inflammation
Ataxia

Adenocarcinoma
Congenital Abnormality
Atrophy
Neurodegenerative Disorders
Myoclonus
Infertility
Lymphoma

Pathways

Localization
Immune Response
Cell Adhesion
Cell Activation
Cell Proliferation
Glycosylation
Cell Death
Pathogenesis
Transport
Cell Migration
Phagocytosis
Cell Differentiation
Exocytosis

Elastic Fiber Assembly
Cytokine Production
Monocyte Differentiation
Secretion
Response To Lipopolysaccharide
Diapedesis
Programmed Cell Death

PTMs

Glycosylation
Phosphorylation

Carboxylation
Cleavage

Biotinylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEU1

References

PMID: 8985184 by Bonten E.J., et al. Characterization of human lysosomal neuraminidase defines the molecular basis of the metabolic storage disorder sialidosis.

PMID: 9020182 by Milner C.M., et al. Identification of a sialidase encoded in the human major histocompatibility complex.