NELFE Antibodies

AND NELFE ELISA kits, NELFE Proteins

Many biological assays use antibodies to detect NELFE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NELFE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NELFE antibodies...

We validate the specificity of these antibodies to NELFE by testing them on tissues known to express NELFE positively and negatively. Browse below to find the NELFE antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NELFE Infographic by Boster Bio

All NELFE Products

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Product

Figures

Specificity

Applications

Price

Anti-Negative elongation factor E NELFE Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A07050
100ul

Human RDBP Recombinant Protein

SDS-PAGE

$250
Cat # PROTP18615
Starting from 20ug

Anti-NELFE Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A07050-1
100 µg/vial

NELFE Overview

Facts about Negative elongation factor E.

NELFE 3D structure. Source: alphafold

Negative elongation factor E (NELFE)

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which functions via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

The NELF complex is included in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA.

Gene Information

Human
Gene Name:	NELFE
Uniprot:	P18615
Entrez:	7936

Family

Belongs to:

RRM NELF-E family

Alternative Names

Negative elongation factor E

Molecular Weight

Mass (kDA):
43.24 kDA

Genomic Context


Human

Location:	6p21.33
Sequence:	6; NC_000006.12 (31952087..31959043, complement)

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Nucleus.

Interacting Proteins

CCDC57
MTUS2
NELFB
TRIM27

PTMs

Isopeptide bond

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NELFE

References

PMID: 2612324 by Speiser P.W., et al. Structure of the human RD gene: a highly conserved gene in the class III region of the major histocompatibility complex.

PMID: 8373374 by Cheng J., et al. cDNA cloning and characterization of the protein encoded by RD, a gene located in the class III region of the human major histocompatibility complex.