NELFCD Antibodies

AND NELFCD ELISA kits, NELFCD Proteins

Many biological assays use antibodies to detect NELFCD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NELFCD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NELFCD antibodies...

We validate the specificity of these antibodies to NELFCD by testing them on tissues known to express NELFCD positively and negatively. Browse below to find the NELFCD antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NELFCD Infographic by Boster Bio

All NELFCD Products

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Specificity

Applications

Price

TH1L (NELFCD) (NM_198976) Human Recombinant Protein

$813
Cat # PROTQ8IXH7
20 µg

TH1L (NELFCD) (NM_198976) Human Over-expression Lysate

Human

$628
Cat # LS051497
100 µg

NELFCD Overview

Facts about Negative elongation factor C/D.

NELFCD 3D structure. Source: alphafold

Negative elongation factor C/D (NELFCD)

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and triggers transcriptional pausing, is counteracted by the P-TEFb kinase complex.

The NELF complex is included in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Binds RNA which might help to stabilize the NELF complex on nucleic acid.

Gene Information

Human
Gene Name:	NELFCD
Uniprot:	Q8IXH7
Entrez:	51497

Family

Belongs to:

NELF-D family

Alternative Names

Negative elongation factor C/D

Molecular Weight

Mass (kDA):
66.247 kDA

Genomic Context


Human

Location:	20q13.32
Sequence:	20; NC_000020.11 (58981252..58995133)

Tissue Specificity

Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas.

Subcellular Localizations

Nucleus.

Interacting Proteins

ARAF
NELFA

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NELFCD

References

PMID: 11030415 by Bonthron D.T., et al. Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13.

PMID: 12612062 by Narita T., et al. Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex.