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NEDD9 Antibodies
AND NEDD9 ELISA kits, NEDD9 Proteins
Many biological assays use antibodies to detect NEDD9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NEDD9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NEDD9 antibodies...
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NEDD9 Infographic by Boster Bio
All NEDD9 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9289
100 μg/vial
Cat # PB9289
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A00838
100ul
Cat # A00838
100ul
NEDD9 Overview
Facts about Enhancer of filamentation 1.
Enhancer of filamentation 1 (NEDD9)
Docking protein that plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in distributing growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell regeneration.
May play an essential role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins such as CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Gene Information
| Human | |
|---|---|
| Gene Name: | NEDD9 |
| Uniprot: | Q14511 |
| Entrez: | 4739 |
Family
| Belongs to: |
|---|
| CAS family |
Alternative Names
Cas scaffolding protein family member 2; CAS2; CASL; CAS-LCASS2cas-like docking; CASLdJ49G10.2; CRK-associated substrate-related protein; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1 (enhancer of filamentation (HEF1)); dJ761I2.1; enhancer of filamentation 1; HEF1; HEF1Crk-associated substrate related; NEDD9; NEDD-9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; p105; Renal carcinoma antigen NY-REN-12
Molecular Weight
Mass (kDA):
92.861 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p24.2 |
| Sequence: | 6; NC_000006.12 (11183298..11382348, complement) |
Tissue Specificity
Widely expressed. Higher levels detected in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. The protein has been detected in lymphocytes, in diverse cell lines, and in lung tissues.
Subcellular Localizations
Cytoplasm, cell cortex. Nucleus. Golgi apparatus. Cell projection, lamellipodium. Cytoplasm. Cell junction, focal adhesion. Localizes to both the cell nucleus and the cell periphery and is differently localized in fibroblasts and epithelial cells. In fibroblasts is predominantly nuclear and in some cells is present in the Golgi apparatus. In epithelial cells localized predominantly in the cell periphery with particular concentration in lamellipodia but is also found in the nucleus. Isoforms p105 and p115 are predominantly cytoplasmic and associate with focal adhesions while p55 associates with
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Cell Invasion
- Melanoma
- Malignant Neoplasm Of Breast
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Invasiveness
- Alzheimer's Disease
- Mammary Neoplasms
Interacting Proteins
- BANP
- BCAR3
- NAB2
- NFKBIA
- PRR20C
- RBPMS
- REL
- RFX6
- TRIM27
- TRIP6
Pathways
- Cell Migration
- Cell Cycle
- Cell Adhesion
- Cell Motility
- Mitosis
- Cell Division
- Cell Proliferation
- Localization
- T Cell Migration
- Cell Activation
- Cell Differentiation
- Cell Death
- Cell Growth
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NEDD9
bosterbio.com/bosterbio-gene-info-cards/NEDD9
References
PMID: 8668148 by Law S.F., et al. Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
PMID: 8879209 by Minegishi M., et al. Structure and function of Cas-L, a 105-kD Crk-associated substrate- related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes.