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NDUFS4 Antibodies
AND NDUFS4 ELISA kits, NDUFS4 Proteins
Many biological assays use antibodies to detect NDUFS4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NDUFS4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NDUFS4 antibodies...
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NDUFS4 Infographic by Boster Bio
All NDUFS4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$370
Cat # M03608-1
100 μl/vial
Cat # M03608-1
100 μl/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03608-2
100 μl/vial
Cat # M03608-2
100 μl/vial
NDUFS4 Overview
Facts about NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial.
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (NDUFS4)
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.
The immediate electron acceptor for the enzyme is believed to be ubiquinone. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NDUFS4 |
| Uniprot: | O43181 |
| Entrez: | 4724 |
Family
| Belongs to: |
|---|
| complex I NDUFS4 subunit family |
Alternative Names
AQDQ; AQDQmitochondrial; CI-18 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 4 (18kD) (NADH-coenzyme Qreductase); NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Qreductase); NADH-coenzyme Q reductase, 18-KD; NADH-ubiquinone oxidoreductase 18 kDa subunit
Molecular Weight
Mass (kDA):
20.108 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.2 |
| Sequence: | 5; NC_000005.10 (53560610..53683338) |
Subcellular Localizations
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Diseases
- Nicotinamide Adenine Dinucleotide Coenzyme Q Reductase Deficiency
- Leigh Disease
- Mitochondrial Diseases
- Parkinson Disease
- Mitochondrial Encephalomyopathies
- Nervous System Disorder
- Encephalopathies
- Hereditary Diseases
- Nerve Degeneration
- Neurodegenerative Disorders
- Respiration Abnormal
Pathways
- Oxidative Phosphorylation
- Neuron Death
- Translation
- Cell Death
- Pathogenesis
- Protein Phosphorylation
- Transport
- Righting Reflex
- Electron Transport
- Aging
- Brain Development
- Glycosylation
PTMs
- Phosphorylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDUFS4
bosterbio.com/bosterbio-gene-info-cards/NDUFS4
References
PMID: 9463323 by van den Heuvel L., et al. Demonstration of a new pathogenic mutation in human complex I deficiency: a 5-bp duplication in the nuclear gene encoding the 18-kD (AQDQ) subunit.
PMID: 12616398 by Benit P., et al. Genotyping microsatellite DNA markers at putative disease loci in inbred/multiplex families with respiratory chain complex I deficiency allows rapid identification of a novel nonsense mutation (IVS1nt -1) in the NDUFS4 gene in Leigh syndrome.