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Protein NDRG1 Antibodies
AND NDRG1 ELISA kits, Protein NDRG1 Proteins
Many biological assays use antibodies to detect Protein NDRG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein NDRG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein NDRG1 antibodies...
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NDRG1 Infographic by Boster Bio
All NDRG1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M01327-1
100 μl
Cat # M01327-1
100 μl
NDRG1 Overview
Facts about Protein NDRG1.
Protein NDRG1 (NDRG1)
Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis.
Has a role in cell trafficking, especially of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF.
Gene Information
| Human | |
|---|---|
| Gene Name: | NDRG1 |
| Uniprot: | Q92597 |
| Entrez: | 10397 |
Family
| Belongs to: |
|---|
| NDRG family |
Alternative Names
CAP43; CMT4D; Differentiation-related gene 1 protein; DRG1; DRG-1; DRG1HMSNL; GC4; HMSNL; NDR1; NDRG1; Nickel-specific induction protein Cap43; NMSL; N-myc downstream regulated 1; N-myc downstream-regulated gene 1 protein; protein NDRG1; protein regulated by oxygen-1; PROXY1; Reducing agents and tunicamycin-responsive protein; RIT42; RTP; RTPGC4; TARG1; TDD5; tunicamycin-responsive protein
Molecular Weight
Mass (kDA):
42.835 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.22 |
| Sequence: | 8; NC_000008.11 (133237175..133297252, complement) |
Tissue Specificity
Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granul
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Hypoxia
- Cell Invasion
- Malignant Neoplasm Of Prostate
- Malignant Neoplasm Of Breast
- Prostatic Neoplasms
- Mammary Neoplasms
- Charcot-marie-tooth Disease
- Neoplasm Invasiveness
Interacting Proteins
- AK6
- CANX
- CTNNB1
- XRCC6
Pathways
- Cell Proliferation
- Cell Cycle
- Cell Differentiation
- Cell Growth
- Angiogenesis
- Cell Death
- Pathogenesis
- Cell Migration
- Cell Cycle Arrest
- Localization
- Rna Interference
- Cell Adhesion
- Myelination
PTMs
- Phosphorylation
- Methylation
- Cleavage
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NDRG1
bosterbio.com/bosterbio-gene-info-cards/NDRG1
References
PMID: 8939898 by Kokame K., et al. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes.
PMID: 9251681 by van Belzen N., et al. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms.