Nck-associated protein 1 Antibodies

AND NCKAP1 ELISA kits, Nck-associated protein 1 Proteins

Many biological assays use antibodies to detect Nck-associated protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nck-associated protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nck-associated protein 1 antibodies...

We validate the specificity of these antibodies to Nck-associated protein 1 by testing them on tissues known to express NCKAP1 positively and negatively. Browse below to find the NCKAP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NCKAP1 Infographic by Boster Bio

All NCKAP1 Products

Product

Figures

Specificity

Applications

Price

Anti-NCKAP1 Antibody Picoband™

5 Q&As

Human, Mouse, Rat

$370
Cat # A09238-1
100 μg/vial

NCKAP1 (NM_013436) Human Over-expression Lysate

Human

$628
Cat # LS010787
100 µg

NCKAP1 Overview

Facts about Nck-associated protein 1.

NCKAP1 3D structure. Source: alphafold

Nck-associated protein 1 (NCKAP1)

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization through its interaction with the Arp2/3 complex.

Actin remodeling activity is governed by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.

Gene Information

Human
Gene Name:	NCKAP1
Uniprot:	Q9Y2A7
Entrez:	10787

Family

Belongs to:

HEM-1/HEM-2 family

Alternative Names

FLJ11291; HEM2p125Nap1; KIAA0587; Membrane-associated protein HEM-2; MGC8981; NAP 1; NAP125; NAP1Nap1; NCK-associated protein 1

Molecular Weight

Mass (kDA):
128.79 kDA

Genomic Context


Human

Location:	2q32.1
Sequence:	2; NC_000002.12 (182909115..183038457, complement)

Tissue Specificity

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Subcellular Localizations

Cell membrane; Single-pass membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Single-pass membrane protein; Cytoplasmic side. At the interface between the lamellipodial actin meshwork and the membrane.

Diseases

Alzheimer's Disease
Neuroblastoma
Tumor Angiogenesis
Malignant Neoplasms
Cns Disorder
Neoplasms
Hemorrhage
Nervousness

Neurodegenerative Disorders
Protrusion
Wiskott-aldrich Syndrome

Interacting Proteins

ABI1
CYFIP1

Pathways

Cell Motility
Actin Nucleation
Drug Resistance
Cell Growth
Angiogenesis
Rna Interference

Secretion

PTMs

Acetylation

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCKAP1

References

PMID: 10673335 by Suzuki T., et al. Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.

PMID: 25121749 by Stanton R.J., et al. HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells.