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- Table of Contents
Facts about Condensin complex subunit 2.
Early in neurogenesis, may play a vital role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately impacting neuron pool and cortex size (PubMed:27737959). .
Human | |
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Gene Name: | NCAPH |
Uniprot: | Q15003 |
Entrez: | 23397 |
Belongs to: |
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CND2 (condensin subunit 2) family |
barren (Drosophila) homolog; barren homolog (Drosophila); barren homolog 1 (Drosophila); barren homolog 1; Barren homolog protein 1; BRRN; BRRN1CAP-H; CAPH; Chromosome-associated protein H; condensin complex subunit 2; HCAP-H; KIAA0074; Non-SMC condensin I complex subunit H; non-SMC condensin I complex, subunit H; XCAP-H homolog
Mass (kDA):
82.563 kDA
Human | |
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Location: | 2q11.2 |
Sequence: | 2; NC_000002.12 (96335766..96377091) |
Widely expressed at low level. Expressed in proliferating cells.
Nucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
PMID: 11694586 by Cabello O.A., et al. Cell cycle-dependent expression and nucleolar localization of hCAP- H.
PMID: 11136719 by Kimura K., et al. Chromosome condensation by a human condensin complex in Xenopus egg extracts.