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Nibrin Antibodies
AND NBN ELISA kits, Nibrin Proteins
Many biological assays use antibodies to detect Nibrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nibrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nibrin antibodies...
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NBN Infographic by Boster Bio
All NBN Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # PB9615
100 μg/vial
Cat # PB9615
100 μg/vial
Human
IP, IF, ICC, WB
$370
Cat # P00732
100 μl
Cat # P00732
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00732
100 μl
Cat # M00732
100 μl
Human
ELISA
$480
Cat # EKC1435
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1435
1 kit, containing one 96-well plate and all necessary reagents
Human
ELISA
$540
Cat # EKC2336
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2336
1 kit, containing two 96-well plates and all necessary reagents
Human, Rat
ELISA
$540
Cat # EKC2468
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2468
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00732-1
100 μg/vial
Cat # M00732-1
100 μg/vial
NBN Overview
Facts about Nibrin.
Nibrin (NBN)
Part of the MRE11-RAD50-NBN (MRN complex) which plays a vital role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11.
RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruitment PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions.
Gene Information
| Human | |
|---|---|
| Gene Name: | NBN |
| Uniprot: | O60934 |
| Entrez: | 4683 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ATV; AT-V1; AT-V2; Cell cycle regulatory protein p95; FLJ10155; MGC87362; NBN; Nbs1; NBS1P95; NBSNijmegen breakage syndrome protein 1; Nibrin; Nijmegen breakage syndrome 1 (nibrin); p95 protein of the MRE11/RAD50 complex; p95
Molecular Weight
Mass (kDA):
84.959 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q21.3 |
| Sequence: | 8; NC_000008.11 (89933331..89984724, complement) |
Tissue Specificity
Ubiquitous. Expressed at high levels in testis.
Subcellular Localizations
Nucleus. Nucleus, PML body. Chromosome, telomere. Chromosome. Localizes to discrete nuclear foci after treatment with genotoxic agents.
Diseases
- Malignant Neoplasms
- Nijmegen Breakage Syndrome
- Ataxia Telangiectasia
- Neoplasms
- Ataxia
- Malignant Neoplasm Of Breast
- Telangiectasis
- Immunologic Deficiency Syndromes
- Mammary Neoplasms
- Chromosome Breakage
- Microcephaly
- Genomic Instability
Interacting Proteins
- ATM
- EP300
- FANCD2
- H2AFX
- INTS3
- MDC1
- MRE11
- RAD17
- RBBP8
- SIRT1
Pathways
- Dna Repair
- Cell Cycle
- Double-strand Break Repair
- Dna Replication
- S Phase
- Hypersensitivity
- Dna Damage Checkpoint
- Cell Cycle Checkpoint
- Telomere Maintenance
- Localization
- Response To Ionizing Radiation
- Pathogenesis
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Ubiquitination
- Acetylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- Chromatin Research
- DNA Double Strand Break Repair
- DNA Repair
- Homologous Recombination
- Non-homologous end-joining
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NBN
bosterbio.com/bosterbio-gene-info-cards/NBN
References
PMID: 9590180 by Varon R., et al. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.
PMID: 9590181 by Carney J.P., et al. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.